Strain differences of rat liver carboxylesterase activities related to the phenotype difference of esterase-3 (egasyn)

T. Nakamura, T. Satoh, T. Horie, F. Sagami, O. Tagaya

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It was demonstrated that the inbred strain EHBR had the C phenotype of esterase-3 judging from the absence of liver microsomal β-glucuronidase and the pattern of esterase activities of liver homogenates after analytical isoelectric focusing. In addition, in the strain EHBR, liver microsomal hydrolase activities of acetanilide and isocarboxazid which are hydrolyzed well by esterase-3 were lower than in outbred Sprague-Dawley rat and inbred LEW rat having the D phenotype of esterase-3. These results suggest that the phenotype difference of esterase-3 is possible to cause the strain differences of liver microsomal carboxylesterase activities.

Original languageEnglish
Pages (from-to)451-459
Number of pages9
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume66
Issue number3
Publication statusPublished - 1989 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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