Strategic Synthesis of Asymmetrically Substituted C4N4 Fluorophores

Wei Xu, Miki Kohei, Masakatsu Shibasaki, Naoya Kumagai

Research output: Contribution to journalArticlepeer-review

Abstract

C4N4 fluorophores comprise a recently disclosed new class of emissive organic molecules with modular synthetic capabilities. Herein, we report a new synthetic protocol toward asymmetrically di arylated C4N4 fluorescent materials. Direct monoarylation of 1-naphthol is exploited to suppress undesired diarylation and to provide a free phenolic hydroxy group for prospective linking to a molecule of interest. Installation of the second aromatic unit in order to acquire fluorescent properties is achieved by Suzuki-Miyaura cross-coupling.

Original languageEnglish
Pages (from-to)3355-3360
Number of pages6
JournalSynthesis (Germany)
Volume53
Issue number18
DOIs
Publication statusPublished - 2021 Sep 16

Keywords

  • aluminum
  • C4N4 fluorophore
  • direct arylation
  • fluorescence
  • fluorescent probe
  • pyrimidine
  • quantum yield

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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