Strategy of drug development based on the bioactive gas-carrying capacity of hemoglobin

Kazuaki Taguchi, Kazuaki Matsumoto, Toru Maruyama, Masaki Otagiri

Research output: Contribution to journalReview article

Abstract

Bioactive gas molecules, including oxygen, nitric oxide and carbon monoxide (CO), exhibit a variety of physiological activities, and are associated with the onset and progress of some disorders. These facts have led researchers to the development of bioactive gas donors for the treatment of intractable disorders. Hemoglobin is likely an ideal carrier of bioactive gases, since hemoglobin in red blood cells innately carries oxygen in the form of oxyhemoglobin, nitric oxide in the form of S-nitrosohemoglobin, and CO in the form of carbonylhemoglobin. In this study, we attempted to develop a biomimetic CO delivery system using a preparation of hemoglobin. Our strategy for the preparation of this hemoglobin-based CO carrier involves CO being exogenously bound to red blood cells or hemoglobin-encapsulated liposomes, called hemoglobin-vesicles (HbV), which mimic the structure and function of red blood cells. We accumulated evidence that the CO donors-CO-bound red blood cells and CO-bound HbV-showed therapeutic efficacy against intractable disorders in animal models. Here, we describe the potential of hemoglobin-based CO donors, especially CO-bound red blood cells and CO-bound HbV, for the treatment of certain disorders. Hemoglobin-based strategies for the delivery of other bioactive gases for novel drug development are also discussed.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalYakugaku Zasshi
Volume140
Issue number2
DOIs
Publication statusPublished - 2020 Feb 1

Keywords

  • Carbon monoxide
  • Heme
  • Hemoglobin
  • Liposome
  • Red blood cell

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Strategy of drug development based on the bioactive gas-carrying capacity of hemoglobin'. Together they form a unique fingerprint.

  • Cite this