Stress on a postpartum mother inhibits the secretion of growth hormone in the offspring and causes persistent growth impairment

H. Nakata, Kenji Watanabe, Y. Murakami, P. Gao, K. Tsuiji, K. Nishimura, G. A. Plotnikoff, N. Kurihara, Y. Irie, A. Ishige

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Children exposed to environmental stress in the early neonatal period often develop psychiatric or somatic diseases in adulthood. In the present study in mice, we examined how postpartum stress on the mother influences their pups and thus tried to provide new insight into the management of idiopathic short stature. The dams were exposed to daily 3-h immobilization stress (IS) only for 3 weeks from the day after delivery. When compared to the pups of nonstressed dams (control pups), those of the IS dams (IS pups) showed lower body weight and height, which persisted even into adulthood. Their nutritional status was normal. The IS pups also showed low serum concentrations of insulin-like growth factor I (IGF-I) and poor responses to growth hormone-releasing hormone (GHRH) stimulation on day 22 and were behaviorally hyperactive at 8 weeks. Immunohistochemical analysis demonstrated that the number of pituitary GH-positive cells in response to treatment with GHRH was markedly decreased in the IS pups compared to the control pups. The IS dams did not show apparent behavioral abnormalities except downregulation of glucocorticoid receptor (GR) gene expression in the hippocampus. These results suggest that the perturbation of GH secretion in the pituitary glands is involved in the lifelong growth impairment of the IS pups.

Original languageEnglish
Pages (from-to)433-441
Number of pages9
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume31
Issue number7
DOIs
Publication statusPublished - 2009

Fingerprint

Immobilization
Postpartum Period
Growth Hormone
Mothers
Growth
Growth Hormone-Releasing Hormone
Somatotrophs
Body Height
Glucocorticoid Receptors
Pituitary Gland
Nutritional Status
Insulin-Like Growth Factor I
Psychiatry
Hippocampus
Down-Regulation
Body Weight
Gene Expression
Serum

Keywords

  • GH-positive cells
  • Growth impairment
  • IGF-I
  • Immobilization stress
  • Immunohistochemistry
  • Postpartum
  • Short stature

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Stress on a postpartum mother inhibits the secretion of growth hormone in the offspring and causes persistent growth impairment. / Nakata, H.; Watanabe, Kenji; Murakami, Y.; Gao, P.; Tsuiji, K.; Nishimura, K.; Plotnikoff, G. A.; Kurihara, N.; Irie, Y.; Ishige, A.

In: Methods and Findings in Experimental and Clinical Pharmacology, Vol. 31, No. 7, 2009, p. 433-441.

Research output: Contribution to journalArticle

Nakata, H, Watanabe, K, Murakami, Y, Gao, P, Tsuiji, K, Nishimura, K, Plotnikoff, GA, Kurihara, N, Irie, Y & Ishige, A 2009, 'Stress on a postpartum mother inhibits the secretion of growth hormone in the offspring and causes persistent growth impairment', Methods and Findings in Experimental and Clinical Pharmacology, vol. 31, no. 7, pp. 433-441. https://doi.org/10.1358/mf.2009.31.7.1415892
Nakata, H. ; Watanabe, Kenji ; Murakami, Y. ; Gao, P. ; Tsuiji, K. ; Nishimura, K. ; Plotnikoff, G. A. ; Kurihara, N. ; Irie, Y. ; Ishige, A. / Stress on a postpartum mother inhibits the secretion of growth hormone in the offspring and causes persistent growth impairment. In: Methods and Findings in Experimental and Clinical Pharmacology. 2009 ; Vol. 31, No. 7. pp. 433-441.
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