Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Youcef Bouchekioua; Iku Tsutsui-Kimura; Hiromi Sano; Miwako Koizumi; Kenji F. Tanaka; Keitaro Yoshida; Yutaka Kosaki; Shigeru Watanabe; Masaru Mimura

doi:10.1016/j.neures.2017.09.007

Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Youcef Bouchekioua, Iku Tsutsui-Kimura, Hiromi Sano, Miwako Koizumi, Kenji F. Tanaka, Keitaro Yoshida, Yutaka Kosaki, Shigeru Watanabe, Masaru Mimura

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

Original language	English
Pages (from-to)	53-57
Number of pages	5
Journal	Neuroscience Research
Volume	132
DOIs	https://doi.org/10.1016/j.neures.2017.09.007
Publication status	Published - 2018 Jul

Keywords

Autistic spectrum disorder (ASD)
D1-MSNs
Direct pathway
Obsessive-compulsive spectrum disorders (OCSD)
Optogenetics
Repetitive behaviors
Striato-nigral pathway
Tourette syndrom

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neures.2017.09.007

Cite this

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title = "Striatonigral direct pathway activation is sufficient to induce repetitive behaviors",

abstract = "Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.",

keywords = "Autistic spectrum disorder (ASD), D1-MSNs, Direct pathway, Obsessive-compulsive spectrum disorders (OCSD), Optogenetics, Repetitive behaviors, Striato-nigral pathway, Tourette syndrom",

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T1 - Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

AU - Bouchekioua, Youcef

AU - Tsutsui-Kimura, Iku

AU - Sano, Hiromi

AU - Koizumi, Miwako

AU - Tanaka, Kenji F.

AU - Yoshida, Keitaro

AU - Kosaki, Yutaka

AU - Watanabe, Shigeru

AU - Mimura, Masaru

PY - 2018/7

Y1 - 2018/7

N2 - Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

AB - Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

KW - Autistic spectrum disorder (ASD)

KW - D1-MSNs

KW - Direct pathway

KW - Obsessive-compulsive spectrum disorders (OCSD)

KW - Optogenetics

KW - Repetitive behaviors

KW - Striato-nigral pathway

KW - Tourette syndrom

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JO - Neuroscience Research

JF - Neuroscience Research

ER -

Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Abstract

Keywords

ASJC Scopus subject areas

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