Striking the balance between PTEN and PDK1

It all depends on the cell context

Akio Iwanami, Timothy F. Cloughesy, Paul S. Mischel

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The phosphatidyl-inosital-3 kinase (PI3K) signaling pathway is critical for normal brain development and function and is commonly hyperactivated in brain cancer. The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor protein and phosphate-depended kinase 1 (PDK-1) are critical regulators of this pathway. In the July 15, 2009, issue of Genes & Development, Chalhoub and colleagues (pp. 1619-1624) demonstrate PDK1-dependent and PDK1-independent effects of conditional PTEN deletion in the brain, and they identify cell type-specific differences in feedback regulation of the PI3K pathway. These studies provide important insights as to how neurons and glia may differentially regulate PI3K signaling, yielding intriguing clues about targeting PTEN-deficient brain cancers.

Original languageEnglish
Pages (from-to)1699-1704
Number of pages6
JournalGenes and Development
Volume23
Issue number15
DOIs
Publication statusPublished - 2009 Aug 1
Externally publishedYes

Fingerprint

Phosphotransferases
Critical Pathways
Brain Neoplasms
PTEN Phosphohydrolase
Tumor Suppressor Proteins
Chromosomes, Human, Pair 10
Brain
Neuroglia
Phosphates
Neurons
Genes

Keywords

  • Brain
  • Feedback
  • Migration
  • Pdk1
  • PI3K
  • Pten

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Striking the balance between PTEN and PDK1 : It all depends on the cell context. / Iwanami, Akio; Cloughesy, Timothy F.; Mischel, Paul S.

In: Genes and Development, Vol. 23, No. 15, 01.08.2009, p. 1699-1704.

Research output: Contribution to journalArticle

Iwanami, Akio ; Cloughesy, Timothy F. ; Mischel, Paul S. / Striking the balance between PTEN and PDK1 : It all depends on the cell context. In: Genes and Development. 2009 ; Vol. 23, No. 15. pp. 1699-1704.
@article{d03a71ea88eb4e93b24aadf9141d7537,
title = "Striking the balance between PTEN and PDK1: It all depends on the cell context",
abstract = "The phosphatidyl-inosital-3 kinase (PI3K) signaling pathway is critical for normal brain development and function and is commonly hyperactivated in brain cancer. The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor protein and phosphate-depended kinase 1 (PDK-1) are critical regulators of this pathway. In the July 15, 2009, issue of Genes & Development, Chalhoub and colleagues (pp. 1619-1624) demonstrate PDK1-dependent and PDK1-independent effects of conditional PTEN deletion in the brain, and they identify cell type-specific differences in feedback regulation of the PI3K pathway. These studies provide important insights as to how neurons and glia may differentially regulate PI3K signaling, yielding intriguing clues about targeting PTEN-deficient brain cancers.",
keywords = "Brain, Feedback, Migration, Pdk1, PI3K, Pten",
author = "Akio Iwanami and Cloughesy, {Timothy F.} and Mischel, {Paul S.}",
year = "2009",
month = "8",
day = "1",
doi = "10.1101/gad.1832909",
language = "English",
volume = "23",
pages = "1699--1704",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "15",

}

TY - JOUR

T1 - Striking the balance between PTEN and PDK1

T2 - It all depends on the cell context

AU - Iwanami, Akio

AU - Cloughesy, Timothy F.

AU - Mischel, Paul S.

PY - 2009/8/1

Y1 - 2009/8/1

N2 - The phosphatidyl-inosital-3 kinase (PI3K) signaling pathway is critical for normal brain development and function and is commonly hyperactivated in brain cancer. The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor protein and phosphate-depended kinase 1 (PDK-1) are critical regulators of this pathway. In the July 15, 2009, issue of Genes & Development, Chalhoub and colleagues (pp. 1619-1624) demonstrate PDK1-dependent and PDK1-independent effects of conditional PTEN deletion in the brain, and they identify cell type-specific differences in feedback regulation of the PI3K pathway. These studies provide important insights as to how neurons and glia may differentially regulate PI3K signaling, yielding intriguing clues about targeting PTEN-deficient brain cancers.

AB - The phosphatidyl-inosital-3 kinase (PI3K) signaling pathway is critical for normal brain development and function and is commonly hyperactivated in brain cancer. The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor protein and phosphate-depended kinase 1 (PDK-1) are critical regulators of this pathway. In the July 15, 2009, issue of Genes & Development, Chalhoub and colleagues (pp. 1619-1624) demonstrate PDK1-dependent and PDK1-independent effects of conditional PTEN deletion in the brain, and they identify cell type-specific differences in feedback regulation of the PI3K pathway. These studies provide important insights as to how neurons and glia may differentially regulate PI3K signaling, yielding intriguing clues about targeting PTEN-deficient brain cancers.

KW - Brain

KW - Feedback

KW - Migration

KW - Pdk1

KW - PI3K

KW - Pten

UR - http://www.scopus.com/inward/record.url?scp=68149132193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68149132193&partnerID=8YFLogxK

U2 - 10.1101/gad.1832909

DO - 10.1101/gad.1832909

M3 - Article

VL - 23

SP - 1699

EP - 1704

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 15

ER -