Strokes Associated with Pregnancy and Puerperium: A Nationwide Study by the Japan Stroke Society

Kazumichi Yoshida, Jun C. Takahashi, Yohei Takenobu, Norihiro Suzuki, Akira Ogawa, Susumu Miyamoto

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background and Purpose - The incidence and cause of strokes associated with pregnancy and the puerperium are still not fully understood. The aim of this study was to characterize pregnancy-related strokes in Japan using a large-scale survey with current imaging techniques. Methods - A retrospective analysis was conducted based on clinical chart reviews in 736 stroke teaching hospitals certified by the Japan Stroke Society between 2012 and 2013, using a web-based questionnaire requesting the detailed clinical course without any personally identifying information. The collection rate of this questionnaire was 70.5%, with 151 pregnancy-associated strokes extracted. Results - Hemorrhagic strokes were observed in 111 cases (73.5%), ischemic strokes in 37 (24.5%), and mixed type in 3 cases (2.0%). The estimated incidence of pregnancy-associated stroke was 10.2 per 100 000 deliveries. Major causes of hemorrhage were aneurysm (19.8%), arteriovenous malformation (17.1%), pregnancy-induced hypertension (11.7%), and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count) (8.1%). Preexisting cerebrovascular diseases responsible for hemorrhage were detected in 59 cases (53.1%). Among the ischemic strokes, 28 (75.7%) were arterial and 9 (24.3%) were venous infarctions. The most frequent cause of arterial infarctions was reversible cerebral vasoconstriction syndrome. Hemorrhagic stroke showed much poorer prognosis than ischemic stroke. Conclusions - The incidence of pregnancy-associated stroke in Japan did not seem higher than that in other Asian and Western countries. The proportion of hemorrhagic stroke among Japanese women was much higher than that in white women. Preexisting cerebrovascular diseases and reversible cerebral vasoconstriction syndrome play a key role in hemorrhagic and ischemic stroke, respectively.

Original languageEnglish
Pages (from-to)276-282
Number of pages7
JournalStroke
Volume48
Issue number2
DOIs
Publication statusPublished - 2017 Feb 1

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Postpartum Period
Japan
Stroke
Pregnancy
Cerebrovascular Disorders
Preexisting Condition Coverage
Vasoconstriction
Infarction
Incidence
HELLP Syndrome
Hemorrhage
Pregnancy Induced Hypertension
Arteriovenous Malformations
Hemolysis
Platelet Count
Teaching Hospitals
Aneurysm

Keywords

  • cerebrovascular diseases
  • gestational age
  • morbidity
  • pregnancy
  • prognosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Yoshida, K., Takahashi, J. C., Takenobu, Y., Suzuki, N., Ogawa, A., & Miyamoto, S. (2017). Strokes Associated with Pregnancy and Puerperium: A Nationwide Study by the Japan Stroke Society. Stroke, 48(2), 276-282. https://doi.org/10.1161/STROKEAHA.116.014406

Strokes Associated with Pregnancy and Puerperium : A Nationwide Study by the Japan Stroke Society. / Yoshida, Kazumichi; Takahashi, Jun C.; Takenobu, Yohei; Suzuki, Norihiro; Ogawa, Akira; Miyamoto, Susumu.

In: Stroke, Vol. 48, No. 2, 01.02.2017, p. 276-282.

Research output: Contribution to journalArticle

Yoshida, K, Takahashi, JC, Takenobu, Y, Suzuki, N, Ogawa, A & Miyamoto, S 2017, 'Strokes Associated with Pregnancy and Puerperium: A Nationwide Study by the Japan Stroke Society', Stroke, vol. 48, no. 2, pp. 276-282. https://doi.org/10.1161/STROKEAHA.116.014406
Yoshida K, Takahashi JC, Takenobu Y, Suzuki N, Ogawa A, Miyamoto S. Strokes Associated with Pregnancy and Puerperium: A Nationwide Study by the Japan Stroke Society. Stroke. 2017 Feb 1;48(2):276-282. https://doi.org/10.1161/STROKEAHA.116.014406
Yoshida, Kazumichi ; Takahashi, Jun C. ; Takenobu, Yohei ; Suzuki, Norihiro ; Ogawa, Akira ; Miyamoto, Susumu. / Strokes Associated with Pregnancy and Puerperium : A Nationwide Study by the Japan Stroke Society. In: Stroke. 2017 ; Vol. 48, No. 2. pp. 276-282.
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