Stromal cell-derived factor-1 chemokine gene polymorphism is not associated with onset age of japanese type 1 diabetes

Toshikatsu Shigihara, Akira Shimada, Satoru Yamada, Taro Maruyama, Hiroshi Hirose, Takao Saruta

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Type 1 diabetes is characterized by cell-mediated autoimmune destruction of pancreatic beta cells. Although the disease shows a strong association with HLA class II alleles, other genes may influence the initiation or the rate of progression of the autoimmune process. Recently, it was reported that a polymorphism of the stromal cell-derived factor-1 (SDF-1) (a kind of chemokine) gene was associated with early onset of type 1 diabetes in Caucasians. Therefore, we examined SDF-1 gene polymorphism In Japanese type 1 diabetes in this study. We examined the SDF-1 gene polymorphism (801G→A) in 298 unrelated Japanese type 1 diabetic patients and 270 healthy subjects by the TaqMan PCR method. Allelic and genotypic frequencies of the SDF-1 A variants were similar in overall type 1 diabetic patients and healthy subjects. We then stratified the patients by their onset pattern (acute vs. slow onset) and islet-associated autoantibody positivity. However, no significant difference was found among each group of type 1 diabetes. Furthermore, unlike the previous report in "Caucasian" type 1 diabetics, the SDF-1 A variant was not associated with early onset of the disease in Japanese type 1 diabetics. The SDF-1 gene polymorphism was not associated with onset age (or onset pattern) of type 1 diabetes in Japanese. Further study is necessary to conclude whether SDF-1 gene polymorphism affects the onset age in type 1 diabetes in general.

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume1005
DOIs
Publication statusPublished - 2003 Jan 1

Keywords

  • Gene polymorphism
  • Stromal cell-derived factor-1
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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