Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study

Satoshi Umeda, Neil A. Harrison, Marcus A. Gray, Christopher J. Mathias, Hugo D. Critchley

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Postural tachycardia syndrome (PoTS), a form of dysautonomia, is characterized by orthostatic intolerance, and is frequently accompanied by a range of symptoms including palpitations, lightheadedness, clouding of thought, blurred vision, fatigue, anxiety, and depression. Although the estimated prevalence of PoTS is approximately 5-10 times as common as the better-known condition orthostatic hypotension, the neural substrates of the syndrome are poorly characterized. In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS. We recruited 11 patients with established PoTS and 23 age-matched normal controls. Group comparison of gray matter volume revealed diminished gray matter volume within the left anterior insula, right middle frontal gyrus and right cingulate gyrus in the PoTS group. We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients. Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores. Together, these findings of structural differences, particularly within insular and cingulate components of the salience network, suggest a link between dysregulated physiological reactions arising from compromised central autonomic control (and interoceptive representation) and increased vulnerability to psychiatric symptoms in PoTS patients.

Original languageEnglish
Article number34
JournalFrontiers in Neuroscience
Volume9
Issue numberMAR
DOIs
Publication statusPublished - 2015

Fingerprint

Postural Orthostatic Tachycardia Syndrome
Brain
Anxiety
Orthostatic Intolerance
Primary Dysautonomias
Depression
Orthostatic Hypotension
Somatosensory Cortex
Gyrus Cinguli
Dizziness
Frontal Lobe
Prefrontal Cortex
Fatigue
Psychiatry
Magnetic Resonance Imaging

Keywords

  • Anxiety
  • Autonomic disorders
  • BM DARTEL
  • Depression
  • Insula
  • Interoception
  • Postural tachycardia syndrome
  • Salience network

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Structural brain abnormalities in postural tachycardia syndrome : A VBM-DARTEL study. / Umeda, Satoshi; Harrison, Neil A.; Gray, Marcus A.; Mathias, Christopher J.; Critchley, Hugo D.

In: Frontiers in Neuroscience, Vol. 9, No. MAR, 34, 2015.

Research output: Contribution to journalArticle

Umeda, Satoshi ; Harrison, Neil A. ; Gray, Marcus A. ; Mathias, Christopher J. ; Critchley, Hugo D. / Structural brain abnormalities in postural tachycardia syndrome : A VBM-DARTEL study. In: Frontiers in Neuroscience. 2015 ; Vol. 9, No. MAR.
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