Structural emphysema does not correlate with lung compliance: Lessons from the mouse smoking model

Robert F. Foronjy, Becky A. Mercer, Mark W. Maxfield, Charles A. Powell, Jeanine D'Armiento, Yasunori Okada

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57 Citations (Scopus)

Abstract

The murine smoke-induced model produces histologic emphysema. The authors sought to assess whether the structural emphysema that occurred correlated with the development of compliance changes. The study exposed 2 strains of mice (CBA/J/Jx C57BL/ 6J and A/J) to chronic cigarette smoke. Lung compliance and morphometry were measured. The smoking model generated significant emphysema in A/J mice in the absence of changes in compliance, lung matrix, or apoptosis. Importantly, there was no correlation between the emphysema measured by lung morphometry and pulmonary compliance. This lack of correlation suggests that the mechanisms involved in anatomic emphysema may be distinct from those that cause the loss of elastic recoil.

Original languageEnglish
Pages (from-to)547-562
Number of pages16
JournalExperimental Lung Research
Volume31
Issue number6
DOIs
Publication statusPublished - 2005 Jul 1

Keywords

  • Compliance
  • Emphysema
  • Morphometry

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry

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    Foronjy, R. F., Mercer, B. A., Maxfield, M. W., Powell, C. A., D'Armiento, J., & Okada, Y. (2005). Structural emphysema does not correlate with lung compliance: Lessons from the mouse smoking model. Experimental Lung Research, 31(6), 547-562. https://doi.org/10.1080/019021490951522