TY - JOUR
T1 - Structural requirements of dictyopyrones isolated from Dictyostelium spp. in the regulation of Dictyostelium development and in anti-leukemic activity
AU - Kikuchi, Haruhisa
AU - Sasaki, Kazunori
AU - Sekiya, Jun'ichi
AU - Maeda, Yasuo
AU - Amagai, Aiko
AU - Kubohara, Yuzuru
AU - Oshima, Yoshiteru
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research (No. 15710153) from the Ministry of Education, Science, Sports and Culture of Japan, and a scholarship from Mitsubishi Trust Yamamuro memorial scholarship foundation.
PY - 2004/6/15
Y1 - 2004/6/15
N2 - Cellular slime molds are fascinating to the field of developmental biology, and have long been used as excellent model organisms for the study of various aspects of multicellular development. We have recently isolated α-pyronoids, named dictyopyrones A-D (1-4), from various species of Dictyostelium cellular slime molds, and it was shown that compound 3 may regulate Dictyostelium development. In this study, we synthesized dictyopyrones A-D (1-4) and their analogues, investigated the physiological role of the molecules in cell growth and morphogenesis in D. discoideum, and further verified their effects on human leukemia K562 cells. Nitrogen-containing compounds 22 and 37 strongly inhibited cell growth in K562 leukemia cells, indicating that these compounds may be utilized as novel lead compounds for anti-leukemic agents.
AB - Cellular slime molds are fascinating to the field of developmental biology, and have long been used as excellent model organisms for the study of various aspects of multicellular development. We have recently isolated α-pyronoids, named dictyopyrones A-D (1-4), from various species of Dictyostelium cellular slime molds, and it was shown that compound 3 may regulate Dictyostelium development. In this study, we synthesized dictyopyrones A-D (1-4) and their analogues, investigated the physiological role of the molecules in cell growth and morphogenesis in D. discoideum, and further verified their effects on human leukemia K562 cells. Nitrogen-containing compounds 22 and 37 strongly inhibited cell growth in K562 leukemia cells, indicating that these compounds may be utilized as novel lead compounds for anti-leukemic agents.
KW - Anti-leukemic activity
KW - Cellular slime molds
KW - Dictyostelium discoideum
KW - α-pyrone
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U2 - 10.1016/j.bmc.2004.04.001
DO - 10.1016/j.bmc.2004.04.001
M3 - Article
C2 - 15158788
AN - SCOPUS:2542466859
SN - 0968-0896
VL - 12
SP - 3203
EP - 3214
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 12
ER -