Abstract
Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.
| Original language | English |
|---|---|
| Pages (from-to) | 9009-9012 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 38 |
| Issue number | 52 |
| Publication status | Published - 1997 Dec 29 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Structurally simplified zaragozic acid (squalestatin) : Stereoselective preparation of a 3,4-unsubstituted derivative. / Ito, Hisanaka; Matsumoto, Miyoko; Yoshizawa, Takeshi; Takao, Kenichi; Kobayashi, Susumu.
In: Tetrahedron Letters, Vol. 38, No. 52, 29.12.1997, p. 9009-9012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structurally simplified zaragozic acid (squalestatin)
T2 - Stereoselective preparation of a 3,4-unsubstituted derivative
AU - Ito, Hisanaka
AU - Matsumoto, Miyoko
AU - Yoshizawa, Takeshi
AU - Takao, Kenichi
AU - Kobayashi, Susumu
PY - 1997/12/29
Y1 - 1997/12/29
N2 - Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.
AB - Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.
UR - http://www.scopus.com/inward/record.url?scp=0030823093&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030823093&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0030823093
VL - 38
SP - 9009
EP - 9012
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 52
ER -