TY - JOUR
T1 - Structurally simplified zaragozic acid (squalestatin)
T2 - Stereoselective preparation of a 3,4-unsubstituted derivative
AU - Ito, Hisanaka
AU - Matsumoto, Miyoko
AU - Yoshizawa, Takeshi
AU - Takao, Ken Ichi
AU - Kobayashi, Susumu
PY - 1997/12/29
Y1 - 1997/12/29
N2 - Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.
AB - Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.
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U2 - 10.1016/S0040-4039(97)10407-5
DO - 10.1016/S0040-4039(97)10407-5
M3 - Article
AN - SCOPUS:0030823093
VL - 38
SP - 9009
EP - 9012
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 52
ER -