Structurally simplified zaragozic acid (squalestatin): Stereoselective preparation of a 3,4-unsubstituted derivative

Hisanaka Ito, Miyoko Matsumoto, Takeshi Yoshizawa, Ken Ichi Takao, Susumu Kobayashi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.

Original languageEnglish
Pages (from-to)9009-9012
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number52
DOIs
Publication statusPublished - 1997 Dec 29
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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