Abstract
Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.
| Original language | English |
|---|---|
| Pages (from-to) | 9009-9012 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 38 |
| Issue number | 52 |
| DOIs | |
| Publication status | Published - 1997 Dec 29 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Ito, H., Matsumoto, M., Yoshizawa, T., Takao, K. I., & Kobayashi, S. (1997). Structurally simplified zaragozic acid (squalestatin): Stereoselective preparation of a 3,4-unsubstituted derivative. Tetrahedron Letters, 38(52), 9009-9012. https://doi.org/10.1016/S0040-4039(97)10407-5