Structure-activity relationships of nitrosamines and nitramines which stimulate UDP-glucuronosyltransferase activities in vitro

Michio Matsui, Fusako Nagai, Emako Suzuki, Masashi Okada

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Examination of twelve nitrosamines and seven nitramines revealed that nitramines modify UDP-glucuronosyltransferase activity in a manner similar to that of nitrosamines. Only N,N-diethyl-substituted nitrosamine and nitramine significantly stimulated transferase activity toward 2-aminophenol and 4-nitrophenol but not toward phenolphthalein and androsterone. Elongation of the alkyl chains or introduction of carboxy, hydroxy, or oxo groups into the alkyl chains did not result in stimulatory ability, and some of these compounds inhibited the transferase activity.

Original languageEnglish
Pages (from-to)2647-2651
Number of pages5
JournalBiochemical Pharmacology
Volume33
Issue number16
DOIs
Publication statusPublished - 1984 Aug 15

Fingerprint

Nitrosamines
Glucuronosyltransferase
Structure-Activity Relationship
Transferases
Phenolphthalein
Androsterone
Elongation
In Vitro Techniques
nitramine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Structure-activity relationships of nitrosamines and nitramines which stimulate UDP-glucuronosyltransferase activities in vitro. / Matsui, Michio; Nagai, Fusako; Suzuki, Emako; Okada, Masashi.

In: Biochemical Pharmacology, Vol. 33, No. 16, 15.08.1984, p. 2647-2651.

Research output: Contribution to journalArticle

Matsui, Michio ; Nagai, Fusako ; Suzuki, Emako ; Okada, Masashi. / Structure-activity relationships of nitrosamines and nitramines which stimulate UDP-glucuronosyltransferase activities in vitro. In: Biochemical Pharmacology. 1984 ; Vol. 33, No. 16. pp. 2647-2651.
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