Structure, function and formation of glycans in Drosophila

Miki Yamamoto-Hino, Hideyuki Okano, Osamu Kanie, Satoshi Goto

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Glycosylation of proteins shows two striking features: first, there are a large number of glycan structures that are involved in various biological events (diversity) and, second, certain structures are selectively added to specific sites within proteins (specificity) in a context-dependent manner. However, the mechanisms that regulate diversity and specificity are unknown. Over the last few decades, genetic studies in Drosophila have been used to examine the functions mediated by glycosylation in vivo. Recent improvements in the combined use of biochemical/biophysical, genetic, and cell biology approaches has allowed the rapid and detailed analysis of the structure, function and formation of glycans in Drosophila. This chapter aims to provide an overview of the different types of glycans and their biological function(s) in Drosophila. The regulation of glycan synthesis in Drosophila and mammals is also discussed.

Original languageEnglish
Title of host publicationGlycans
Subtitle of host publicationBiochemistry, Characterization and Applications
PublisherNova Science Publishers, Inc.
Pages165-188
Number of pages24
ISBN (Print)9781619425415
Publication statusPublished - 2012 Feb 1

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Yamamoto-Hino, M., Okano, H., Kanie, O., & Goto, S. (2012). Structure, function and formation of glycans in Drosophila. In Glycans: Biochemistry, Characterization and Applications (pp. 165-188). Nova Science Publishers, Inc..