Structure of arnebinol, a new ANSA-type monoterpenylbenzenoid with inhibitory effect to prostaglandin biosynthesis

Yao Xin-Sheng, Yutaka Ebizuka, Hiroshi Noguchi, Fumiyuki Kiuchi, Yoichi Iitaka, Ushio Sankawa, Haruo Seto

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The two inhibitors of prostaglandin biosynthesis were isolated from the root of Arnebia euchroma (Boraginaceae). A colourless crystalline compound was identified to be a polyketide, des-0-methyllasiodiplodin (3) formerly obtained from a fungus, Lasiodiplodia theobromae. The structure of the other colourless crystalline compound, named arnebinol (1), was deduced from spectral investigations to be a dehydroderivative of geranylhydroquinone and finally determined by X-ray analysis to be a novel ansa-type monoterpenylbenzenoid.

Original languageEnglish
Pages (from-to)2407-2410
Number of pages4
JournalTetrahedron Letters
Volume24
Issue number23
DOIs
Publication statusPublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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