Novel biselyngbyaside analogs, biselyngbyolide C (1) and biselyngbyasides E (2) and F (3), were isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The gross structures of 13 were determined by NMR spectral analyses, and their stereochemistries were established based on NOESY spectra and CD data. These compounds inhibited the growth of HeLa and HL60 cells. From the results of an MTT assay, the geometry of the trisubstituted olefin in the side chain and the lack of the sugar moiety were found to be important for the biological activity. In addition, 1 was found to exhibit ER stress- and apoptosis-inducing activities in HeLa cells.
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