Structures of amamistatins A and B, novel growth inhibitors of human tumor cell lines from Nocardia asteroides

Susumu Kokubo; Kiyotake Suenaga; Chikara Shinohara; Tomoko Tsuji; Daisuke Uemura

doi:10.1016/S0040-4020(00)00591-3

Structures of amamistatins A and B, novel growth inhibitors of human tumor cell lines from Nocardia asteroides

Susumu Kokubo, Kiyotake Suenaga, Chikara Shinohara, Tomoko Tsuji, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Two new lipopeptides, amamistatins A and B, were isolated from Nocardia asteroides SCRC-A2359, and their absolute stereostructures were determined by spectroscopic and chemical analyses. Amamistatin A inhibited the growth of human rumor cell lines. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	6435-6440
Number of pages	6
Journal	Tetrahedron
Volume	56
Issue number	35
DOIs	https://doi.org/10.1016/S0040-4020(00)00591-3
Publication status	Published - 2000 Aug 25
Externally published	Yes

Keywords

Degradation
Oxazoles
Peptides
Stereochemistry

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(00)00591-3

Cite this

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title = "Structures of amamistatins A and B, novel growth inhibitors of human tumor cell lines from Nocardia asteroides",

abstract = "Two new lipopeptides, amamistatins A and B, were isolated from Nocardia asteroides SCRC-A2359, and their absolute stereostructures were determined by spectroscopic and chemical analyses. Amamistatin A inhibited the growth of human rumor cell lines. (C) 2000 Elsevier Science Ltd.",

keywords = "Degradation, Oxazoles, Peptides, Stereochemistry",

author = "Susumu Kokubo and Kiyotake Suenaga and Chikara Shinohara and Tomoko Tsuji and Daisuke Uemura",

note = "Funding Information: This work was supported in part by Wako Pure Chemical Industries Ltd and by Grants-in-Aid (Nos. 11175101 and 12045235) for Scientific Research from the Ministry of Education, Science, Sports, and Culture, Japan. ",

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doi = "10.1016/S0040-4020(00)00591-3",

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T1 - Structures of amamistatins A and B, novel growth inhibitors of human tumor cell lines from Nocardia asteroides

AU - Kokubo, Susumu

AU - Suenaga, Kiyotake

AU - Shinohara, Chikara

AU - Tsuji, Tomoko

AU - Uemura, Daisuke

N1 - Funding Information: This work was supported in part by Wako Pure Chemical Industries Ltd and by Grants-in-Aid (Nos. 11175101 and 12045235) for Scientific Research from the Ministry of Education, Science, Sports, and Culture, Japan.

PY - 2000/8/25

Y1 - 2000/8/25

N2 - Two new lipopeptides, amamistatins A and B, were isolated from Nocardia asteroides SCRC-A2359, and their absolute stereostructures were determined by spectroscopic and chemical analyses. Amamistatin A inhibited the growth of human rumor cell lines. (C) 2000 Elsevier Science Ltd.

AB - Two new lipopeptides, amamistatins A and B, were isolated from Nocardia asteroides SCRC-A2359, and their absolute stereostructures were determined by spectroscopic and chemical analyses. Amamistatin A inhibited the growth of human rumor cell lines. (C) 2000 Elsevier Science Ltd.

KW - Degradation

KW - Oxazoles

KW - Peptides

KW - Stereochemistry

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DO - 10.1016/S0040-4020(00)00591-3

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SN - 0040-4020

VL - 56

SP - 6435

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JO - Tetrahedron

JF - Tetrahedron

IS - 35

ER -

Structures of amamistatins A and B, novel growth inhibitors of human tumor cell lines from Nocardia asteroides

Abstract

Keywords

ASJC Scopus subject areas

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