Structures of amamistatins A and B, novel growth inhibitors of human tumor cell lines from Nocardia asteroides

Susumu Kokubo, Kiyotake Suenaga, Chikara Shinohara, Tomoko Tsuji, Daisuke Uemura

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Two new lipopeptides, amamistatins A and B, were isolated from Nocardia asteroides SCRC-A2359, and their absolute stereostructures were determined by spectroscopic and chemical analyses. Amamistatin A inhibited the growth of human rumor cell lines. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)6435-6440
Number of pages6
JournalTetrahedron
Volume56
Issue number35
DOIs
Publication statusPublished - 2000 Aug 25
Externally publishedYes

Keywords

  • Degradation
  • Oxazoles
  • Peptides
  • Stereochemistry

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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