Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp. and their promoting activities of innate immune responses

Haruhisa Kikuchi, Masato Isobe, Mizuki Sekiya, Yuko Abe, Tsuyoshi Hoshikawa, Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

Innate immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as an innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-α-stimulated production of IL-8 in human umbilical vein endothelial cells.

Original languageEnglish
Pages (from-to)4624-4627
Number of pages4
JournalOrganic Letters
Volume13
Issue number17
DOIs
Publication statusPublished - 2011 Sep 2
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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