TY - JOUR
T1 - Studies on administration of thiamazole to breast-feeding mothers with Graves' disease
AU - Murase, Setsuko
AU - Sato, Toru
AU - Kokubun, Hideya
AU - Kimura, Toshimi
AU - Takahashi, Masaaki
AU - Machida, Mitsuru
AU - Shimada, Shigehiko
AU - Nishikawa, Takashi
AU - Oyama, Tsunehide
AU - Mochizuki, Mayumi
AU - Abe, Yoshifumi
AU - Ito, Kunihiko
PY - 1999
Y1 - 1999
N2 - We investigated the excretion of thiamazole, an antithyroid drug, in the milk of 6 mothers with Graves' disease. Thiamazole in serum or milk was determined by high performance liquid chromatography. The mothers had been taking thiamazole 5∼10 mg/day, before and after delivery. The drug concentration in serum was almost equal to that in milk; it reached maximum at about 2 hours after the previous administration and was considerably decreased at 12 hours. The babies were breast-fed at 12 hours or more after the previous administration, and the drug was not detected (below about 1 ng/ml) in the serum of any baby. Thyroid function test results were normal in all babies. These findings suggest that breast-feeding mothers with hyperthyroidism can continue thiamazole treatment, though further study is needed for assessment of safety, regarding the accumulation of the drug in the thyroid of babies.
AB - We investigated the excretion of thiamazole, an antithyroid drug, in the milk of 6 mothers with Graves' disease. Thiamazole in serum or milk was determined by high performance liquid chromatography. The mothers had been taking thiamazole 5∼10 mg/day, before and after delivery. The drug concentration in serum was almost equal to that in milk; it reached maximum at about 2 hours after the previous administration and was considerably decreased at 12 hours. The babies were breast-fed at 12 hours or more after the previous administration, and the drug was not detected (below about 1 ng/ml) in the serum of any baby. Thyroid function test results were normal in all babies. These findings suggest that breast-feeding mothers with hyperthyroidism can continue thiamazole treatment, though further study is needed for assessment of safety, regarding the accumulation of the drug in the thyroid of babies.
KW - Antithyroid drug
KW - Breast milk
KW - Lactation
KW - Mothers with Graves' disease
KW - Pharmacokinetics of thiamazole
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U2 - 10.3999/jscpt.30.775
DO - 10.3999/jscpt.30.775
M3 - Article
AN - SCOPUS:0041820036
SN - 0388-1601
VL - 30
SP - 775
EP - 782
JO - Japanese Journal of Clinical Pharmacology and Therapeutics
JF - Japanese Journal of Clinical Pharmacology and Therapeutics
IS - 6
ER -