Studies on Crude Drugs Effective on Visceral Larva Migrans. I. Identification of Larvicidal Principles in Betel Nuts

Fumiyuki Kiuchi, Naoshi Miyashita, Yoshisuke Tsuda, Hiroyuki Yoshimura, Kaoru Kondo

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

Larvicidal principles obtained from the 50% aqueous acetone extract of betel nuts (Areca catechu) were revealed to be a mixture of fatty acids. They were identified by GC-MS analysis as lauric, myristic, palmitic, and oleic acids. Determination of the larvicidal activities of fatty acids and aliphatic alcohols with various alkyl chain lengths, and of analogous compounds with various functional groups, suggested that the balance between hydrophilicity and hydrophobicity is important for the larvicidal activity.

Original languageEnglish
Pages (from-to)2880-2886
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume35
Issue number7
DOIs
Publication statusPublished - 1987
Externally publishedYes

Keywords

  • Areca catechu
  • Toxocara canis
  • aliphatic alcohol
  • anthelmintic
  • betel chewing
  • fatty acid
  • larva
  • larvicide
  • tannin

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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