Studies on Crude Drugs Effective on Visceral Larva Migrans. III. The Bursting Activity of Tannins on Dog Roundworm Larva

Fumiyuki Kiuchi, Yoshisuke Tsuda, Kaoru Kondo, Hirotuki Yoshimura, Itsuo Nishioka, Gen ichiro Nonaka

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Tannin, both condensed and hydrolyzable, were found to cause bursting of the second-stage larvae of dog roundworm (Toxocara canis), when combined with an appropriate larvicidal compound such as decanoic acid or tetradecanol. This bursting activity of tannins increased with increase of the degree of condensed tannins and with increase of the proportion of phenolic moieties for hydrolyzable tannins. Since tannins are not larvicidal by themselves, the apperance of this bursting activity requires the coexistence of larvicides. The activity was strongly induced by larvicides with a polar functional group such as an acid or an alcohol, but weakly induced by those with a less polar group such as an amide. Tannins were also found to enhance the killing activity of acid larvicides. These facts suggested the practical effectiveness of the combination of tannins and an appropriate anthelmintic for the treatement of parasitic diseases.

Original languageEnglish
Pages (from-to)1796-1802
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume36
Issue number5
DOIs
Publication statusPublished - 1988 Jan 1
Externally publishedYes

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Keywords

  • Toxocara canis
  • anthelmintic
  • bursting activity
  • condensed tannin
  • hydrolyzable tannin
  • larvicide
  • structure-activity relationship
  • synergistic effect
  • tannin

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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