Abstract
Animal models are important tools for the study of pathophysiology and the developmentof new treatments for mental disorders. A number of animal models of posttraumaticstress disorder (PTSD) have been proposed, and these can be categorizedinto two major groups according to their basic concepts. One idea of model constructionis that stress given to animals should simulate traumatic events in humans.The researchers utilize social stress which is more naturalistic than electric shocksor restraint (Koolhaas et al. 1997). For example, animals are exposed to a predatoror predator odor and the alterations induced by the stress exposure are analyzed.Pathophysiological consequences of predator stress are described by Adamec inChap. 5.In the other animal models of PTSD, researchers focus on the alterations inducedby stress resembling symptoms of PTSD, although the stress paradigm itself is completelyartificial. As was reviewed by Foa et al. (1992), animals exposed to uncontrollableand unpredictable stress showed similar disturbances to those found in PTSD. Because pathogenesis of mental disorders is still unclear, most animal modelsare based on similarities in neurochemical, neurophysiological, or behavioralmanifestations between model animals and clinical observations. However, "facevalidity" is only the first step in establishing a model (Yehuda and Antelman 1993).Therefore, although animal research simplifies the investigation of possible pathophysiologyand molecular mechanisms of human diseases, confirmation in clinicalresearch is needed.
| Original language | English |
|---|---|
| Title of host publication | PTSD: Brain Mechanisms and Clinical Implications |
| Publisher | Springer Japan |
| Pages | 55-59 |
| Number of pages | 5 |
| ISBN (Print) | 9784431295679, 4431295666, 9784431295662 |
| DOIs | |
| Publication status | Published - 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Medicine(all)
- Neuroscience(all)
Cite this
Studies on pathophysiology of PTSD using the SPS model. / Kohda, Kazuhisa; Kato, Kunio; Kato, Nobumasa.
PTSD: Brain Mechanisms and Clinical Implications. Springer Japan, 2006. p. 55-59.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Studies on pathophysiology of PTSD using the SPS model
AU - Kohda, Kazuhisa
AU - Kato, Kunio
AU - Kato, Nobumasa
PY - 2006
Y1 - 2006
N2 - Animal models are important tools for the study of pathophysiology and the developmentof new treatments for mental disorders. A number of animal models of posttraumaticstress disorder (PTSD) have been proposed, and these can be categorizedinto two major groups according to their basic concepts. One idea of model constructionis that stress given to animals should simulate traumatic events in humans.The researchers utilize social stress which is more naturalistic than electric shocksor restraint (Koolhaas et al. 1997). For example, animals are exposed to a predatoror predator odor and the alterations induced by the stress exposure are analyzed.Pathophysiological consequences of predator stress are described by Adamec inChap. 5.In the other animal models of PTSD, researchers focus on the alterations inducedby stress resembling symptoms of PTSD, although the stress paradigm itself is completelyartificial. As was reviewed by Foa et al. (1992), animals exposed to uncontrollableand unpredictable stress showed similar disturbances to those found in PTSD. Because pathogenesis of mental disorders is still unclear, most animal modelsare based on similarities in neurochemical, neurophysiological, or behavioralmanifestations between model animals and clinical observations. However, "facevalidity" is only the first step in establishing a model (Yehuda and Antelman 1993).Therefore, although animal research simplifies the investigation of possible pathophysiologyand molecular mechanisms of human diseases, confirmation in clinicalresearch is needed.
AB - Animal models are important tools for the study of pathophysiology and the developmentof new treatments for mental disorders. A number of animal models of posttraumaticstress disorder (PTSD) have been proposed, and these can be categorizedinto two major groups according to their basic concepts. One idea of model constructionis that stress given to animals should simulate traumatic events in humans.The researchers utilize social stress which is more naturalistic than electric shocksor restraint (Koolhaas et al. 1997). For example, animals are exposed to a predatoror predator odor and the alterations induced by the stress exposure are analyzed.Pathophysiological consequences of predator stress are described by Adamec inChap. 5.In the other animal models of PTSD, researchers focus on the alterations inducedby stress resembling symptoms of PTSD, although the stress paradigm itself is completelyartificial. As was reviewed by Foa et al. (1992), animals exposed to uncontrollableand unpredictable stress showed similar disturbances to those found in PTSD. Because pathogenesis of mental disorders is still unclear, most animal modelsare based on similarities in neurochemical, neurophysiological, or behavioralmanifestations between model animals and clinical observations. However, "facevalidity" is only the first step in establishing a model (Yehuda and Antelman 1993).Therefore, although animal research simplifies the investigation of possible pathophysiologyand molecular mechanisms of human diseases, confirmation in clinicalresearch is needed.
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U2 - 10.1007/4-431-29567-4_6
DO - 10.1007/4-431-29567-4_6
M3 - Chapter
SN - 9784431295679
SN - 4431295666
SN - 9784431295662
SP - 55
EP - 59
BT - PTSD: Brain Mechanisms and Clinical Implications
PB - Springer Japan
ER -