Study of molecular transport through specific liquid in bio-mimetic extended nanospaces

Y. Kazoe, H. Li, H. Chinen, H. Kizoe, T. Saruko, T. Yamashita, K. Mawatari, T. Kitamori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Molecular transport in 100 nm inter/intra cellular spaces such as synaptic clefts and mitochondria has important roles in biological functions. Our group has developed a powerful in vitro tool, i.e., bio-mimetic extended nanospace (10-1000 nm), lipid bilayer-modified extended nanochannel for mimicking the cellular spaces. In this study, we have revealed liquid viscosity and molecular diffusion in bio-mimetic extended nanospace. The diffusion of proteins and ions was much slower by increased viscosity of confined liquid, which is considered to be induced by loosely coupled water molecules within 50 nm of the surface.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1267-1269
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - 2013 Jan 1
Externally publishedYes
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume2

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13/10/2713/10/31

Keywords

  • Bio-mimetics
  • Diffusion
  • Fluid
  • Nanochannel

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Kazoe, Y., Li, H., Chinen, H., Kizoe, H., Saruko, T., Yamashita, T., Mawatari, K., & Kitamori, T. (2013). Study of molecular transport through specific liquid in bio-mimetic extended nanospaces. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (pp. 1267-1269). (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 2). Chemical and Biological Microsystems Society.