Study on DNA-specific suppressor T cell dysfunction in patients with systemic lupus erythematosus (SLE)

Tsutomu Takeuchi, Jun Koide, Osamu Hosono, Tohru Abe, Mitsuo Homma

Research output: Contribution to journalArticle

Abstract

Anti-DNA antibody synthesis by lymphocytes from normal individuals and systemic lupus erythematosus (SLE) patients was investigated. Anti-DNA antibody synthesis in response to DNA was demonstrated in SLE, but not in normal individuals. DNA was T cell-dependent antigen in anti-DNA antibody synthesis. Anti-DNA antibody synthesis by SLE lymphocytes was suppressed by T8 cells and enhanced by T4 cells in inactive stage. However, in active stage, SLE T8 cells failed to suppress anti-DNA antibody synthesis, even in any T4/T8 ratio. These results indicated that DNA-specific suppressor T cell dysfunction was in part responsible for the elevated anti-DNA antibody synthesis in SLE lymphocytes in response to DNA.

Original languageEnglish
Pages (from-to)555-560
Number of pages6
JournalJapanese Journal of Clinical Immunology
Volume6
Issue number6
DOIs
Publication statusPublished - 1983

Fingerprint

Antinuclear Antibodies
Systemic Lupus Erythematosus
T-Lymphocytes
DNA
CD8-Positive T-Lymphocytes
Lymphocytes
CD4-Positive T-Lymphocytes
CD4-CD8 Ratio
Antigens

Keywords

  • anti-DNA antibody
  • DNA
  • SLE
  • T cells
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Study on DNA-specific suppressor T cell dysfunction in patients with systemic lupus erythematosus (SLE). / Takeuchi, Tsutomu; Koide, Jun; Hosono, Osamu; Abe, Tohru; Homma, Mitsuo.

In: Japanese Journal of Clinical Immunology, Vol. 6, No. 6, 1983, p. 555-560.

Research output: Contribution to journalArticle

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