TY - JOUR
T1 - Study on endogenous prostaglandin levels in the gastric mucosa during gastric ulcer healing
AU - Asakura, Hitoshi
AU - Miura, Soichiro
AU - Watanabe, Noriaki
AU - Tanaka, Shin
AU - Watanabe, Mamoru
AU - Iwao, Yasusi
AU - Hamada, Keiki
AU - Morita, Akira
AU - Suyama, Kyoichiro
AU - Tsuchiya, Masaharu
PY - 1989
Y1 - 1989
N2 - In order to clarify the role of mucosal endogenous prostaglandin in the healing process of gastric ulcers, gastric mucosal PGE2 and 6-keto PGF1α contents in the healing process were measured in 17 patients with gastric ulcers and these results were compared between H2-blocker therapy and the combination therapy of H2-blocker and sofalcone. 1) Gastric mucosal PGE2 and 6-keto PGF1α contents were not influenced by H2-blocker therapy and these were significantly increased by the combination therapy. 2) Ratio of PAS stain positive areas per total mucosal areas of gastric ulcer scars was not significantly different between the both therapy, but it had a tendency to be higher in the combination therapy. 3) There was a positive correlation between mucosal PGE2 contents of gastric ulcer scars and ratio of PAS stain positive areas per total mucosal areas. In summary, mucosal endogenous PG may play a role of healing process in gastric ulcers.
AB - In order to clarify the role of mucosal endogenous prostaglandin in the healing process of gastric ulcers, gastric mucosal PGE2 and 6-keto PGF1α contents in the healing process were measured in 17 patients with gastric ulcers and these results were compared between H2-blocker therapy and the combination therapy of H2-blocker and sofalcone. 1) Gastric mucosal PGE2 and 6-keto PGF1α contents were not influenced by H2-blocker therapy and these were significantly increased by the combination therapy. 2) Ratio of PAS stain positive areas per total mucosal areas of gastric ulcer scars was not significantly different between the both therapy, but it had a tendency to be higher in the combination therapy. 3) There was a positive correlation between mucosal PGE2 contents of gastric ulcer scars and ratio of PAS stain positive areas per total mucosal areas. In summary, mucosal endogenous PG may play a role of healing process in gastric ulcers.
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U2 - 10.11280/gee1973b.31.1464
DO - 10.11280/gee1973b.31.1464
M3 - Article
AN - SCOPUS:0024391648
SN - 0387-1207
VL - 31
SP - 1464
EP - 1470
JO - Gastroenterological Endoscopy
JF - Gastroenterological Endoscopy
IS - 6
ER -