Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation: An experimental study using resected porcine esophagus, stomach, and colon

Mitsuhiro Fujishiro, Naohisa Yahagi, Masanori Nakamura, Naomi Kakushima, Shinya Kodashima, Satoshi Ono, Katsuya Kobayashi, Takuhei Hashimoto, Nobutake Yamamichi, Ayako Tateishi, Yasuhito Shimizu, Masashi Oka, Masao Ichinose, Masao Omata

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Argon plasma coagulation (APC) is considered to be a safe thermocoagulation technique, but some reports show perforation and deformity during and after APC. In this study, we investigated the usefulness of prior submucosal injection for APC. APC over the mucosa was performed on fresh resected porcine esophagus, stomach, and colon with prior submucosal injection of normal saline (injection group) and without it (control group). The depth of tissue damage increased linearly with pulse duration up to the shallower submucosal layer in both groups. After that, tissue damage in the injection group remained confined to the shallower submucosal layer under any condition, whereas that in the control group continued to extend. The tissue damages of the injection groups were significantly (P < 0.05) shallower than those of the control groups that reached the deeper submucosal layer in all the organs. Submucosal injection of normal saline before the application of APC may limit tissue damage and prevent perforation and deformity.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalSurgical Laparoscopy, Endoscopy and Percutaneous Techniques
Volume16
Issue number5
DOIs
Publication statusPublished - 2006 Oct
Externally publishedYes

Fingerprint

Argon Plasma Coagulation
Esophagus
Stomach
Colon
Swine
Injections
Control Groups
Electrocoagulation
Mucous Membrane

Keywords

  • Argon plasma coagulation
  • Depth control
  • Endoscopic application
  • Normal saline
  • Submucosal injection
  • The gastrointestinal tract

ASJC Scopus subject areas

  • Surgery

Cite this

Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation : An experimental study using resected porcine esophagus, stomach, and colon. / Fujishiro, Mitsuhiro; Yahagi, Naohisa; Nakamura, Masanori; Kakushima, Naomi; Kodashima, Shinya; Ono, Satoshi; Kobayashi, Katsuya; Hashimoto, Takuhei; Yamamichi, Nobutake; Tateishi, Ayako; Shimizu, Yasuhito; Oka, Masashi; Ichinose, Masao; Omata, Masao.

In: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques, Vol. 16, No. 5, 10.2006, p. 307-311.

Research output: Contribution to journalArticle

Fujishiro, M, Yahagi, N, Nakamura, M, Kakushima, N, Kodashima, S, Ono, S, Kobayashi, K, Hashimoto, T, Yamamichi, N, Tateishi, A, Shimizu, Y, Oka, M, Ichinose, M & Omata, M 2006, 'Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation: An experimental study using resected porcine esophagus, stomach, and colon', Surgical Laparoscopy, Endoscopy and Percutaneous Techniques, vol. 16, no. 5, pp. 307-311. https://doi.org/10.1097/01.sle.0000213739.85277.3d
Fujishiro, Mitsuhiro ; Yahagi, Naohisa ; Nakamura, Masanori ; Kakushima, Naomi ; Kodashima, Shinya ; Ono, Satoshi ; Kobayashi, Katsuya ; Hashimoto, Takuhei ; Yamamichi, Nobutake ; Tateishi, Ayako ; Shimizu, Yasuhito ; Oka, Masashi ; Ichinose, Masao ; Omata, Masao. / Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation : An experimental study using resected porcine esophagus, stomach, and colon. In: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 2006 ; Vol. 16, No. 5. pp. 307-311.
@article{f73a7b71182e4951a34f736f562c7534,
title = "Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation: An experimental study using resected porcine esophagus, stomach, and colon",
abstract = "Argon plasma coagulation (APC) is considered to be a safe thermocoagulation technique, but some reports show perforation and deformity during and after APC. In this study, we investigated the usefulness of prior submucosal injection for APC. APC over the mucosa was performed on fresh resected porcine esophagus, stomach, and colon with prior submucosal injection of normal saline (injection group) and without it (control group). The depth of tissue damage increased linearly with pulse duration up to the shallower submucosal layer in both groups. After that, tissue damage in the injection group remained confined to the shallower submucosal layer under any condition, whereas that in the control group continued to extend. The tissue damages of the injection groups were significantly (P < 0.05) shallower than those of the control groups that reached the deeper submucosal layer in all the organs. Submucosal injection of normal saline before the application of APC may limit tissue damage and prevent perforation and deformity.",
keywords = "Argon plasma coagulation, Depth control, Endoscopic application, Normal saline, Submucosal injection, The gastrointestinal tract",
author = "Mitsuhiro Fujishiro and Naohisa Yahagi and Masanori Nakamura and Naomi Kakushima and Shinya Kodashima and Satoshi Ono and Katsuya Kobayashi and Takuhei Hashimoto and Nobutake Yamamichi and Ayako Tateishi and Yasuhito Shimizu and Masashi Oka and Masao Ichinose and Masao Omata",
year = "2006",
month = "10",
doi = "10.1097/01.sle.0000213739.85277.3d",
language = "English",
volume = "16",
pages = "307--311",
journal = "Surgical Laparoscopy, Endoscopy and Percutaneous Techniques",
issn = "1530-4515",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation

T2 - An experimental study using resected porcine esophagus, stomach, and colon

AU - Fujishiro, Mitsuhiro

AU - Yahagi, Naohisa

AU - Nakamura, Masanori

AU - Kakushima, Naomi

AU - Kodashima, Shinya

AU - Ono, Satoshi

AU - Kobayashi, Katsuya

AU - Hashimoto, Takuhei

AU - Yamamichi, Nobutake

AU - Tateishi, Ayako

AU - Shimizu, Yasuhito

AU - Oka, Masashi

AU - Ichinose, Masao

AU - Omata, Masao

PY - 2006/10

Y1 - 2006/10

N2 - Argon plasma coagulation (APC) is considered to be a safe thermocoagulation technique, but some reports show perforation and deformity during and after APC. In this study, we investigated the usefulness of prior submucosal injection for APC. APC over the mucosa was performed on fresh resected porcine esophagus, stomach, and colon with prior submucosal injection of normal saline (injection group) and without it (control group). The depth of tissue damage increased linearly with pulse duration up to the shallower submucosal layer in both groups. After that, tissue damage in the injection group remained confined to the shallower submucosal layer under any condition, whereas that in the control group continued to extend. The tissue damages of the injection groups were significantly (P < 0.05) shallower than those of the control groups that reached the deeper submucosal layer in all the organs. Submucosal injection of normal saline before the application of APC may limit tissue damage and prevent perforation and deformity.

AB - Argon plasma coagulation (APC) is considered to be a safe thermocoagulation technique, but some reports show perforation and deformity during and after APC. In this study, we investigated the usefulness of prior submucosal injection for APC. APC over the mucosa was performed on fresh resected porcine esophagus, stomach, and colon with prior submucosal injection of normal saline (injection group) and without it (control group). The depth of tissue damage increased linearly with pulse duration up to the shallower submucosal layer in both groups. After that, tissue damage in the injection group remained confined to the shallower submucosal layer under any condition, whereas that in the control group continued to extend. The tissue damages of the injection groups were significantly (P < 0.05) shallower than those of the control groups that reached the deeper submucosal layer in all the organs. Submucosal injection of normal saline before the application of APC may limit tissue damage and prevent perforation and deformity.

KW - Argon plasma coagulation

KW - Depth control

KW - Endoscopic application

KW - Normal saline

KW - Submucosal injection

KW - The gastrointestinal tract

UR - http://www.scopus.com/inward/record.url?scp=33750344070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750344070&partnerID=8YFLogxK

U2 - 10.1097/01.sle.0000213739.85277.3d

DO - 10.1097/01.sle.0000213739.85277.3d

M3 - Article

C2 - 17057569

AN - SCOPUS:33750344070

VL - 16

SP - 307

EP - 311

JO - Surgical Laparoscopy, Endoscopy and Percutaneous Techniques

JF - Surgical Laparoscopy, Endoscopy and Percutaneous Techniques

SN - 1530-4515

IS - 5

ER -