Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation: An experimental study using resected porcine esophagus, stomach, and colon

Mitsuhiro Fujishiro, Naohisa Yahagi, Masanori Nakamura, Naomi Kakushima, Shinya Kodashima, Satoshi Ono, Katsuya Kobayashi, Takuhei Hashimoto, Nobutake Yamamichi, Ayako Tateishi, Yasuhito Shimizu, Masashi Oka, Masao Ichinose, Masao Omata

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Argon plasma coagulation (APC) is considered to be a safe thermocoagulation technique, but some reports show perforation and deformity during and after APC. In this study, we investigated the usefulness of prior submucosal injection for APC. APC over the mucosa was performed on fresh resected porcine esophagus, stomach, and colon with prior submucosal injection of normal saline (injection group) and without it (control group). The depth of tissue damage increased linearly with pulse duration up to the shallower submucosal layer in both groups. After that, tissue damage in the injection group remained confined to the shallower submucosal layer under any condition, whereas that in the control group continued to extend. The tissue damages of the injection groups were significantly (P < 0.05) shallower than those of the control groups that reached the deeper submucosal layer in all the organs. Submucosal injection of normal saline before the application of APC may limit tissue damage and prevent perforation and deformity.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalSurgical Laparoscopy, Endoscopy and Percutaneous Techniques
Volume16
Issue number5
DOIs
Publication statusPublished - 2006 Oct 1
Externally publishedYes

Keywords

  • Argon plasma coagulation
  • Depth control
  • Endoscopic application
  • Normal saline
  • Submucosal injection
  • The gastrointestinal tract

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Fujishiro, M., Yahagi, N., Nakamura, M., Kakushima, N., Kodashima, S., Ono, S., Kobayashi, K., Hashimoto, T., Yamamichi, N., Tateishi, A., Shimizu, Y., Oka, M., Ichinose, M., & Omata, M. (2006). Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation: An experimental study using resected porcine esophagus, stomach, and colon. Surgical Laparoscopy, Endoscopy and Percutaneous Techniques, 16(5), 307-311. https://doi.org/10.1097/01.sle.0000213739.85277.3d