Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement

Mayumi Sugiura-Ogasawara, Koji Aoki, Tomoyuki Fujii, Tomio Fujita, Rie Kawaguchi, Tetsuo Maruyama, Nobuaki Ozawa, Toshitaka Sugi, Toshiyuki Takeshita, Shigeru Saito

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Abstract

Information concerning the prognosis of subsequent pregnancies in patients with reciprocal translocations is limited. This study was performed to determine the percentage success rate with first pregnancies after ascertainment of a carrier status. A total of 2,382 couples with a history of two or more consecutive miscarriages were studied in multicenters. The prevalence of an abnormal chromosome in either partner was examined, and subsequent success rates were compared between cases with and without an abnormal karyotype in either partner. A total of 129 couples (5.4%) had an abnormal karyotype in one partner excluding inversion 9 in 44 men and in 85 women. Thus, 2,253 couples had a normal karyotype in both partner. Eighty-five (3.6%) had translocations, 13 being Robertsonian translocations. Twenty-nine of the 46 cases (63.0%) who became pregnant with reciprocal translocations in either partner experienced a live birth with natural conception. In contrast, 950 of 1,207 cases (78.7%) with normal chromosomes had successful live births, the difference being significant (P = 0.019). No infant with an unbalanced translocation was found in 29 cases of successful pregnancy following recurrent miscarriage. Pregnancy prognosis was worsened with either maternal or paternal reciprocal translocations. Explanation of the success rate with natural conception should be provided before the subsequent pregnancy after ascertainment of carrier status.

Original languageEnglish
Pages (from-to)622-628
Number of pages7
JournalJournal of Human Genetics
Volume53
Issue number7
DOIs
Publication statusPublished - 2008 Jul 1

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Keywords

  • Chromosome abnormality
  • Inversion
  • Reciprocal translocation
  • Recurrent miscarriage
  • Robertsonian translocation

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Sugiura-Ogasawara, M., Aoki, K., Fujii, T., Fujita, T., Kawaguchi, R., Maruyama, T., Ozawa, N., Sugi, T., Takeshita, T., & Saito, S. (2008). Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement. Journal of Human Genetics, 53(7), 622-628. https://doi.org/10.1007/s10038-008-0290-2