Subtype Specification of Cerebral Cortical Neurons in Their Immature Stages

Koji Oishi, Kazunori Nakajima

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Abstract

The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons. Here, we summarize recent findings regarding the regulation of subtype specification during later periods of neuronal differentiation, such as the post-mitotic and post-migratory stages. We also discuss thalamocortical axons as an extra-cortical cue that provides information on the subtype determination of immature cortical neurons.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalNeurochemical Research
DOIs
Publication statusAccepted/In press - 2017 Nov 28

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Keywords

  • Brain development
  • Cerebral cortex
  • Cortical layers
  • Subtype specification

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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