Abstract
In vitro anticancer drug sensitivity tests have been performed for various types of cancers, and a relationship with clinical response has been observed. The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) is a new in vitro anticancer drug sensitivity test by Yabushita et al., recently reported to be useful in ovarian cancer. CD-DST allows analysis of a small number of cells, compared to other anticancer drug sensitivity tests. Here, we report a successful analysis of anticancer drug sensitivity by CD-DST using cancerous ascites and pleural fluid samples from 2 patients with advanced ovarian cancer. To our knowledge, this is only the second report of the application of CD-DST in ovarian cancer, and our results suggest that CD-DST could be helpful in the selection of anticancer drugs for neoadjuvant chemotherapy in advanced ovarian cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 3547-3551 |
| Number of pages | 5 |
| Journal | Anticancer research |
| Volume | 25 |
| Issue number | 5 |
| Publication status | Published - 2005 Sept 1 |
Keywords
- Ascitic fluid
- Collagen gel droplet-embedded culture drug sensitivity test (CD-DST)
- Neoadjuvant chemotherapy
- Ovarian cancer
- Pleural fluid
ASJC Scopus subject areas
- Oncology
- Cancer Research
