Successful analysis of anticancer drug sensitivity by CD-DST using pleural fluid and ascites from patients with advanced ovarian cancer: Case reports

Makiko Kawaguchi, Kouji Banno, Nobuyuki Susumu, Megumi Yanokura, Yoshiko Kuwabara, Nobumaru Hirao, Katsumi Tsukazaki, Shiro Nozawa

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8 Citations (Scopus)

Abstract

In vitro anticancer drug sensitivity tests have been performed for various types of cancers, and a relationship with clinical response has been observed. The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) is a new in vitro anticancer drug sensitivity test by Yabushita et al., recently reported to be useful in ovarian cancer. CD-DST allows analysis of a small number of cells, compared to other anticancer drug sensitivity tests. Here, we report a successful analysis of anticancer drug sensitivity by CD-DST using cancerous ascites and pleural fluid samples from 2 patients with advanced ovarian cancer. To our knowledge, this is only the second report of the application of CD-DST in ovarian cancer, and our results suggest that CD-DST could be helpful in the selection of anticancer drugs for neoadjuvant chemotherapy in advanced ovarian cancer.

Original languageEnglish
Pages (from-to)3547-3551
Number of pages5
JournalAnticancer research
Volume25
Issue number5
Publication statusPublished - 2005 Sep 1

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Keywords

  • Ascitic fluid
  • Collagen gel droplet-embedded culture drug sensitivity test (CD-DST)
  • Neoadjuvant chemotherapy
  • Ovarian cancer
  • Pleural fluid

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kawaguchi, M., Banno, K., Susumu, N., Yanokura, M., Kuwabara, Y., Hirao, N., Tsukazaki, K., & Nozawa, S. (2005). Successful analysis of anticancer drug sensitivity by CD-DST using pleural fluid and ascites from patients with advanced ovarian cancer: Case reports. Anticancer research, 25(5), 3547-3551.