Successful analysis of anticancer drug sensitivity by CD-DST using pleural fluid and ascites from patients with advanced ovarian cancer

Case reports

Makiko Kawaguchi, Kouji Banno, Nobuyuki Susumu, Megumi Yanokura, Yoshiko Kuwabara, Nobumaru Hirao, Katsumi Tsukazaki, Shiro Nozawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In vitro anticancer drug sensitivity tests have been performed for various types of cancers, and a relationship with clinical response has been observed. The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) is a new in vitro anticancer drug sensitivity test by Yabushita et al., recently reported to be useful in ovarian cancer. CD-DST allows analysis of a small number of cells, compared to other anticancer drug sensitivity tests. Here, we report a successful analysis of anticancer drug sensitivity by CD-DST using cancerous ascites and pleural fluid samples from 2 patients with advanced ovarian cancer. To our knowledge, this is only the second report of the application of CD-DST in ovarian cancer, and our results suggest that CD-DST could be helpful in the selection of anticancer drugs for neoadjuvant chemotherapy in advanced ovarian cancer.

Original languageEnglish
Pages (from-to)3547-3551
Number of pages5
JournalAnticancer Research
Volume25
Issue number5
Publication statusPublished - 2005 Sep

Fingerprint

Ascites
Ovarian Neoplasms
Collagen
Antitumor Drug Screening Assays
Gels
Pharmaceutical Preparations
Cell Count
Drug Therapy
Neoplasms

Keywords

  • Ascitic fluid
  • Collagen gel droplet-embedded culture drug sensitivity test (CD-DST)
  • Neoadjuvant chemotherapy
  • Ovarian cancer
  • Pleural fluid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Successful analysis of anticancer drug sensitivity by CD-DST using pleural fluid and ascites from patients with advanced ovarian cancer : Case reports. / Kawaguchi, Makiko; Banno, Kouji; Susumu, Nobuyuki; Yanokura, Megumi; Kuwabara, Yoshiko; Hirao, Nobumaru; Tsukazaki, Katsumi; Nozawa, Shiro.

In: Anticancer Research, Vol. 25, No. 5, 09.2005, p. 3547-3551.

Research output: Contribution to journalArticle

Kawaguchi, M, Banno, K, Susumu, N, Yanokura, M, Kuwabara, Y, Hirao, N, Tsukazaki, K & Nozawa, S 2005, 'Successful analysis of anticancer drug sensitivity by CD-DST using pleural fluid and ascites from patients with advanced ovarian cancer: Case reports', Anticancer Research, vol. 25, no. 5, pp. 3547-3551.
Kawaguchi, Makiko ; Banno, Kouji ; Susumu, Nobuyuki ; Yanokura, Megumi ; Kuwabara, Yoshiko ; Hirao, Nobumaru ; Tsukazaki, Katsumi ; Nozawa, Shiro. / Successful analysis of anticancer drug sensitivity by CD-DST using pleural fluid and ascites from patients with advanced ovarian cancer : Case reports. In: Anticancer Research. 2005 ; Vol. 25, No. 5. pp. 3547-3551.
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