Successful low-dose leflunomide treatment for ganciclovir-resistant cytomegalovirus infection with high-level antigenemia in a kidney transplant: A case report and literature review

Shinya Morita; Kazunobu Shinoda; Satoshi Tamaki; Hidaka Kono; Hiroshi Asanuma; Ken Nakagawa; Mototsugu Oya

doi:10.1016/j.jcv.2016.07.015

Successful low-dose leflunomide treatment for ganciclovir-resistant cytomegalovirus infection with high-level antigenemia in a kidney transplant: A case report and literature review

Shinya Morita, Kazunobu Shinoda, Satoshi Tamaki, Hidaka Kono, Hiroshi Asanuma, Ken Nakagawa, Mototsugu Oya

Department of Urology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Ganciclovir-resistant cytomegalovirus infection is sometimes life-threatening for organ transplant recipients. Foscarnet is an alternative, although it may potentially worsen the preexistent impaired renal function. Here we report the case of a successful low-dose leflunomide treatment in a kidney transplant recipient with very high viral replication, who underwent kidney transplantation 10 years before. Administering 10 mg leflunomide daily for 5 months without a loading dose completely cleared the ganciclovir-resistant cytomegalovirus strains.

Original language	English
Pages (from-to)	133-138
Number of pages	6
Journal	Journal of Clinical Virology
Volume	82
DOIs	https://doi.org/10.1016/j.jcv.2016.07.015
Publication status	Published - 2016 Sept 1

Keywords

Cytomegalovirus
Ganciclovir-resistance
Impaired renal function
Kidney transplantation
Leflunomide

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcv.2016.07.015

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Successful low-dose leflunomide treatment for ganciclovir-resistant cytomegalovirus infection with high-level antigenemia in a kidney transplant : A case report and literature review. / Morita, Shinya; Shinoda, Kazunobu; Tamaki, Satoshi et al.

In: Journal of Clinical Virology, Vol. 82, 01.09.2016, p. 133-138.

Research output: Contribution to journal › Article › peer-review

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abstract = "Ganciclovir-resistant cytomegalovirus infection is sometimes life-threatening for organ transplant recipients. Foscarnet is an alternative, although it may potentially worsen the preexistent impaired renal function. Here we report the case of a successful low-dose leflunomide treatment in a kidney transplant recipient with very high viral replication, who underwent kidney transplantation 10 years before. Administering 10 mg leflunomide daily for 5 months without a loading dose completely cleared the ganciclovir-resistant cytomegalovirus strains.",

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AU - Tamaki, Satoshi

AU - Kono, Hidaka

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AU - Nakagawa, Ken

AU - Oya, Mototsugu

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KW - Ganciclovir-resistance

KW - Impaired renal function

KW - Kidney transplantation

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Successful low-dose leflunomide treatment for ganciclovir-resistant cytomegalovirus infection with high-level antigenemia in a kidney transplant: A case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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