Successful low-dose leflunomide treatment for ganciclovir-resistant cytomegalovirus infection with high-level antigenemia in a kidney transplant: A case report and literature review

Shinya Morita, Kazunobu Shinoda, Satoshi Tamaki, Hidaka Kono, Hiroshi Asanuma, Ken Nakagawa, Mototsugu Oya

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Ganciclovir-resistant cytomegalovirus infection is sometimes life-threatening for organ transplant recipients. Foscarnet is an alternative, although it may potentially worsen the preexistent impaired renal function. Here we report the case of a successful low-dose leflunomide treatment in a kidney transplant recipient with very high viral replication, who underwent kidney transplantation 10 years before. Administering 10 mg leflunomide daily for 5 months without a loading dose completely cleared the ganciclovir-resistant cytomegalovirus strains.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalJournal of Clinical Virology
Volume82
DOIs
Publication statusPublished - 2016 Sep 1

Fingerprint

leflunomide
Ganciclovir
Cytomegalovirus Infections
Foscarnet
Transplants
Kidney
Cytomegalovirus
Kidney Transplantation
Therapeutics
Transplant Recipients

Keywords

  • Cytomegalovirus
  • Ganciclovir-resistance
  • Impaired renal function
  • Kidney transplantation
  • Leflunomide

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

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AU - Morita, Shinya

AU - Shinoda, Kazunobu

AU - Tamaki, Satoshi

AU - Kono, Hidaka

AU - Asanuma, Hiroshi

AU - Nakagawa, Ken

AU - Oya, Mototsugu

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AB - Ganciclovir-resistant cytomegalovirus infection is sometimes life-threatening for organ transplant recipients. Foscarnet is an alternative, although it may potentially worsen the preexistent impaired renal function. Here we report the case of a successful low-dose leflunomide treatment in a kidney transplant recipient with very high viral replication, who underwent kidney transplantation 10 years before. Administering 10 mg leflunomide daily for 5 months without a loading dose completely cleared the ganciclovir-resistant cytomegalovirus strains.

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