Successful preoperative intra-arterial chemotherapy and concurrent radiotherapy for recurrent chest wall malignant fibrous histiocytoma

A case of malignant fibrous histiocytoma (MFH) of the chest wall is reported. A fifty-nine-year-old male admitted into our hospital suffering from a giant chest wall tumor that had recurred after three separate resections. Thrice preoperative intra-arterial infusions of ADR 50 mg/m², CDDP 100 mg/m² and ADR 50 mg/m² were respectively administered along with 60 Gy of concurrent radiotherapy. After that, we widely resected the tumor, chest wall, clavicle, subclavian vein and part of the deltoid muscle. The defect of the chest wall was reconstructed with Marlex-Mesh and covered with a rectus abdominis muscle flap. No viable tumor cells were detected in the resected specimen. Aggressive preoperative chemoradiotherapy was very useful for the treatment of MFH in this case.