Successful Steroid Therapy for Lipoid Pneumonia Developing After Allogeneic Hematopoietic Stem Cell Transplant

A Case Report

Masatoshi Sakurai, Jun Kato, T. Toyama, R. Hashida, Y. Yamane, R. Abe, Yuya Koda, S. Kohashi, Taku Kikuchi, Yuichiro Hayashi, S. Nukaga, Soichiro Ueda, Koichi Fukunaga, Shinichiro Okamoto, Takehiko Mori

Research output: Contribution to journalArticle

Abstract

Lipoid pneumonia is an uncommon noninfectious inflammatory lung disease characterized by lipid deposition in the alveoli, and its etiology and treatment have not been elucidated. We report the case of a 32-year-old woman who developed lipoid pneumonia 9 months after allogeneic hematopoietic stem cell transplant for chronic myelogenous leukemia in lymphoid blast crisis. She complained of progressive cough and dyspnea shortly after discontinuation of immunosuppressive therapy given for graft-vs-host disease. Computed tomography demonstrated diffuse ground-glass opacities in the lungs, and pulmonary function test revealed restrictive impairment. Bronchoalveolar lavage fluid showed milky appearance, and transbronchial lung biopsy specimen revealed foamy macrophages infiltrating the alveoli. Based on these findings, she was diagnosed as having lipoid pneumonia. Prednisolone (1 mg/kg/d) promptly improved the symptoms, pulmonary shadows, and pulmonary function. The findings and clinical course of this case suggest that lipoid pneumonia should be recognized as one of the pulmonary complications of allogeneic hematopoietic stem cell transplantation.

Original languageEnglish
Pages (from-to)4096-4098
Number of pages3
JournalTransplantation Proceedings
Volume50
Issue number10
DOIs
Publication statusPublished - 2018 Dec 1

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Hematopoietic Stem Cells
Pneumonia
Steroids
Transplants
Lung
Respiratory Function Tests
Blast Crisis
Hematopoietic Stem Cell Transplantation
Bronchoalveolar Lavage Fluid
Graft vs Host Disease
Therapeutics
Immunosuppressive Agents
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Prednisolone
Cough
Dyspnea
Lung Diseases
Glass
Macrophages
Tomography

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Successful Steroid Therapy for Lipoid Pneumonia Developing After Allogeneic Hematopoietic Stem Cell Transplant : A Case Report. / Sakurai, Masatoshi; Kato, Jun; Toyama, T.; Hashida, R.; Yamane, Y.; Abe, R.; Koda, Yuya; Kohashi, S.; Kikuchi, Taku; Hayashi, Yuichiro; Nukaga, S.; Ueda, Soichiro; Fukunaga, Koichi; Okamoto, Shinichiro; Mori, Takehiko.

In: Transplantation Proceedings, Vol. 50, No. 10, 01.12.2018, p. 4096-4098.

Research output: Contribution to journalArticle

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