TY - JOUR
T1 - Successful Steroid Therapy for Lipoid Pneumonia Developing After Allogeneic Hematopoietic Stem Cell Transplant
T2 - A Case Report
AU - Sakurai, M.
AU - Kato, J.
AU - Toyama, Takaaki
AU - Hashida, R.
AU - Yamane, Y.
AU - Abe, Ryohei
AU - Koda, Y.
AU - Kohashi, Sumiko
AU - Kikuchi, Taku
AU - Hayashi, Y.
AU - Nukaga, S.
AU - Ueda, S.
AU - Fukunaga, K.
AU - Okamoto, Shinichiro
AU - Mori, Takehiko
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Lipoid pneumonia is an uncommon noninfectious inflammatory lung disease characterized by lipid deposition in the alveoli, and its etiology and treatment have not been elucidated. We report the case of a 32-year-old woman who developed lipoid pneumonia 9 months after allogeneic hematopoietic stem cell transplant for chronic myelogenous leukemia in lymphoid blast crisis. She complained of progressive cough and dyspnea shortly after discontinuation of immunosuppressive therapy given for graft-vs-host disease. Computed tomography demonstrated diffuse ground-glass opacities in the lungs, and pulmonary function test revealed restrictive impairment. Bronchoalveolar lavage fluid showed milky appearance, and transbronchial lung biopsy specimen revealed foamy macrophages infiltrating the alveoli. Based on these findings, she was diagnosed as having lipoid pneumonia. Prednisolone (1 mg/kg/d) promptly improved the symptoms, pulmonary shadows, and pulmonary function. The findings and clinical course of this case suggest that lipoid pneumonia should be recognized as one of the pulmonary complications of allogeneic hematopoietic stem cell transplantation.
AB - Lipoid pneumonia is an uncommon noninfectious inflammatory lung disease characterized by lipid deposition in the alveoli, and its etiology and treatment have not been elucidated. We report the case of a 32-year-old woman who developed lipoid pneumonia 9 months after allogeneic hematopoietic stem cell transplant for chronic myelogenous leukemia in lymphoid blast crisis. She complained of progressive cough and dyspnea shortly after discontinuation of immunosuppressive therapy given for graft-vs-host disease. Computed tomography demonstrated diffuse ground-glass opacities in the lungs, and pulmonary function test revealed restrictive impairment. Bronchoalveolar lavage fluid showed milky appearance, and transbronchial lung biopsy specimen revealed foamy macrophages infiltrating the alveoli. Based on these findings, she was diagnosed as having lipoid pneumonia. Prednisolone (1 mg/kg/d) promptly improved the symptoms, pulmonary shadows, and pulmonary function. The findings and clinical course of this case suggest that lipoid pneumonia should be recognized as one of the pulmonary complications of allogeneic hematopoietic stem cell transplantation.
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U2 - 10.1016/j.transproceed.2018.09.004
DO - 10.1016/j.transproceed.2018.09.004
M3 - Article
C2 - 30577323
AN - SCOPUS:85058515352
SN - 0041-1345
VL - 50
SP - 4096
EP - 4098
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 10
ER -