TY - JOUR
T1 - Successful Surgical Treatment Combined With Infliximab in a Patient With Acute Aortic Regurgitation Caused by Behçet Disease
AU - Kawakubo, Yumiko
AU - Katsumata, Yoshinori
AU - Komuro, Jin
AU - Shiraishi, Yasuyuki
AU - Yuasa, Shinsuke
AU - Itabashi, Yuji
AU - Kono, Takashi
AU - Fukuda, Keiichi
N1 - Funding Information:
Dr Shiraishi is affiliated with a department endowed by Nippon Shinyaku Co, Ltd, and received a research grant from the SECOM Science and Technology Foundation, and received an honorarium from Otsuka Pharmaceutical Co, Ltd.
Publisher Copyright:
© 2020 Canadian Cardiovascular Society
PY - 2020/7
Y1 - 2020/7
N2 - Standard aortic valve replacement for aortic regurgitation caused by Behçet disease (BD) is frequently complicated by postoperative recurrent prosthetic valve detachment. Tumour necrosis factor (TNF) α is known to be associated with higher inflammation activities. Therefore, the concomitant use of immunomodulatory agents with TNFα inhibitors may be the key to a better outcome. This is a case report of a 46-year-old woman with severe acute aortic regurgitation due to BD. Immunosuppressive therapy including the TNFα inhibitor infliximab, which has not been reported for perioperative use to date, resulted in the prompt remission of inflammation, leading to the success of Bentall surgery.
AB - Standard aortic valve replacement for aortic regurgitation caused by Behçet disease (BD) is frequently complicated by postoperative recurrent prosthetic valve detachment. Tumour necrosis factor (TNF) α is known to be associated with higher inflammation activities. Therefore, the concomitant use of immunomodulatory agents with TNFα inhibitors may be the key to a better outcome. This is a case report of a 46-year-old woman with severe acute aortic regurgitation due to BD. Immunosuppressive therapy including the TNFα inhibitor infliximab, which has not been reported for perioperative use to date, resulted in the prompt remission of inflammation, leading to the success of Bentall surgery.
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U2 - 10.1016/j.cjca.2020.03.029
DO - 10.1016/j.cjca.2020.03.029
M3 - Article
C2 - 32502427
AN - SCOPUS:85087993949
SN - 0828-282X
VL - 36
SP - 1161.e3-1161.e5
JO - Canadian Journal of Cardiology
JF - Canadian Journal of Cardiology
IS - 7
ER -