Successful Surgical Treatment Combined With Infliximab in a Patient With Acute Aortic Regurgitation Caused by Behçet Disease

Yumiko Kawakubo, Yoshinori Katsumata, Jin Komuro, Yasuyuki Shiraishi, Shinsuke Yuasa, Yuji Itabashi, Takashi Kohno, Keiichi Fukuda

Research output: Contribution to journalArticle

Abstract

Standard aortic valve replacement for aortic regurgitation caused by Behçet disease (BD) is frequently complicated by postoperative recurrent prosthetic valve detachment. Tumour necrosis factor (TNF) α is known to be associated with higher inflammation activities. Therefore, the concomitant use of immunomodulatory agents with TNFα inhibitors may be the key to a better outcome. This is a case report of a 46-year-old woman with severe acute aortic regurgitation due to BD. Immunosuppressive therapy including the TNFα inhibitor infliximab, which has not been reported for perioperative use to date, resulted in the prompt remission of inflammation, leading to the success of Bentall surgery.

Original languageEnglish
Pages (from-to)1161.e3-1161.e5
JournalCanadian Journal of Cardiology
Volume36
Issue number7
DOIs
Publication statusPublished - 2020 Jul

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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