Successful Tear Lipid Layer Treatment for Refractory Dry Eye in Office Workers by Low-Dose Lipid Application on the Full-Length Eyelid Margin

Eiki Goto, Murat Dogru, Kazumi Fukagawa, Miki Uchino, Yukihiro Matsumoto, Megumi Saiki, Kazuo Tsubota

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Purpose: To test tear lipid layer treatment by low-dose lipid application on the full-length eyelid margin for the treatment of office workers with dry eyes refractory to conventional treatments. Design: Prospective interventional case series. Methods: Thirty eyes of 30 office workers with dry eyes with dark tear interference images, which did not respond to conventional treatments, were included. To supply lipid using a commercially available nonpreserved topical medication having both polar and nonpolar lipid base, ofloxacin eye ointment (Santen Pharmaceutical, Osaka, Japan) was selected. Low-dose ofloxacin ointment application on the full-length eyelid margin was carried out three times a day for two weeks. The symptom of ocular dryness using a visual analog scale, tear interferometry to assess lipid layer thickness (LLT), corneal fluorescein staining, tear-film breakup time (BUT), and meibum expressibility gradings were compared. Results: After the treatment, the symptom score of ocular dryness decreased from 91.4 ± 11.9 to 33.6 ± 21.0 (P < .0001), LLT increased from 39 ± 4 nm to 161 ± 91 nm (P < .0001), BUT was prolonged from 2.6 ± 1.6 seconds to 4.8 ± 2.1 seconds (P = .01), and meibum expressibility gradings decreased from 2.8 ± 1.3 to 1.6 ± 1.3 (P = .0005). Conclusion: For office workers with refractory dry eyes, tear lipid layer treatment by low-dose ointment applied on the full-length eyelid margin was shown to be an effective approach. The applied lipid formed a uniform lipid layer, which contributed to tear stability, leading to the improvement of the symptom.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume142
Issue number2
DOIs
Publication statusPublished - 2006 Aug

Fingerprint

Eyelids
Tears
Lipids
Ointments
Ofloxacin
Interferometry
Fluorescein
Visual Analog Scale
Japan
Staining and Labeling

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Successful Tear Lipid Layer Treatment for Refractory Dry Eye in Office Workers by Low-Dose Lipid Application on the Full-Length Eyelid Margin. / Goto, Eiki; Dogru, Murat; Fukagawa, Kazumi; Uchino, Miki; Matsumoto, Yukihiro; Saiki, Megumi; Tsubota, Kazuo.

In: American Journal of Ophthalmology, Vol. 142, No. 2, 08.2006.

Research output: Contribution to journalArticle

Goto, Eiki ; Dogru, Murat ; Fukagawa, Kazumi ; Uchino, Miki ; Matsumoto, Yukihiro ; Saiki, Megumi ; Tsubota, Kazuo. / Successful Tear Lipid Layer Treatment for Refractory Dry Eye in Office Workers by Low-Dose Lipid Application on the Full-Length Eyelid Margin. In: American Journal of Ophthalmology. 2006 ; Vol. 142, No. 2.
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