Successful treatment of acute kidney injury in patients with idiopathic nephrotic syndrome using human atrial natriuretic peptide

Kohei Ueda, Junichi Hirahashi, George Seki, Mototsugu Tanaka, Natsuki Kushida, Yusuke Takeshima, Yoshitaka Nishikawa, Toshiro Fujita, Masaomi Nangaku

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The acute onset of idiopathic nephrotic syndrome (NS) is often accompanied by acute kidney injury, which can lead to congestive heart failure and lung edema. In this report, we present two cases of NS-induced acute kidney injury successfully treated with a low dose of carperitide, a human atrial natriuretic peptide. In combination with standard diuretic therapy and immunotherapy, carperitide retained the renal function and spared the need for renal replacement therapy, including hemodialysis. Although further investigation in clinical trials is required to validate these findings, carperitide may be useful for maintaining the renal function in cases of NS-induced acute kidney injury.

Original languageEnglish
Pages (from-to)865-869
Number of pages5
JournalInternal Medicine
Volume53
Issue number8
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Acute kidney injury
  • Human atrial natriuretic peptide
  • Nephrotic syndrome

ASJC Scopus subject areas

  • Internal Medicine

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