Successful treatment of dopamine dysregulation syndrome with dopamine D 2 partial agonist antipsychotic drug

Jin Mizushima, Keisuke Takahata, Noriko Kawashima, Motoichiro Kato

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Dopamine dysregulation syndrome (DDS) consists of a series of complications such as compulsive use of dopaminergic medications, aggressive or hypomanic behaviors during excessive use, and withdrawal states characterized by dysphoria and anxiety, caused by long-term dopaminergic treatment in patients with Parkinson's disease (PD). Although several ways to manage DDS have been suggested, there has been no established treatment that can manage DDS without deterioration of motor symptoms. In this article, we present a case of PD in whom the administration of the dopamine D 2 partial agonistic antipsychotic drug aripiprazole improved DDS symptoms such as craving and compulsive behavior without worsening of motor symptoms. Considering the profile of this drug as a partial agonist at D 2 receptors, it is possible that it exerts its therapeutic effect on DDS by modulating the dysfunctional dopamine system.

Original languageEnglish
Article number19
JournalAnnals of General Psychiatry
Publication statusPublished - 2012 Jul 7
Externally publishedYes


  • Aripiprazole
  • Dopamine d2 partial agonistic antipsychotic drug
  • Dopamine dysregulation syndrome (dds)
  • Dopamine replacement therapy (drt)
  • Parkinson's disease

ASJC Scopus subject areas

  • Psychiatry and Mental health


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