Successful treatment with L-asparaginase-based combination chemotherapy for refractory T-cell post-transplant lymphoproliferative disorder

A. Mihara, Chien Kang Chen, Kenji Yokoyama, Tomoki Ueda, Yuiko Tsukada, Norihiro Awaya, Takehiko Mori, Yasuo Ikeda, Shinichiro Okamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 31-year-old man underwent kidney transplantation in 1996, and had been on immunosuppressants. In 2005, he presented with discomfort on swallowing. Swelling of the left tonsil and a mediastinal mass were observed. A biopsy of the left tonsil showed a monotonous proliferation of atypical lymphocytes suggesting post-transplant lymphoproliferative disorder (PTLD). The reduction of immunosuppressants did not result in any clinical improvements, and he developed bilateral cervical lymphadenopathy. A biopsy of the cervical lymph node also showed monotonous proliferation of TdT, CD3, CD5, CD7, CD10, and CD34-positive immature cells. T-cell receptor rearrangement, but not EBER, was detected. Based on these findings, monomorphic T-cell PTLD was diagnosed. He was treated with four different chemotherapeutic regimens without any clinical improvements, and the PTLD became leukemic. Chemotherapy consisting of L-asparaginase, vincristine, and dexamethasone (LVD) was then given, which resulted in massive tumor lysis. However, after two courses of LVD, complete remission was achieved. T-cell PTLD is a rare disorder, characterized by its refractoriness to chemotherapy as opposed to B-cell PTLD. Our experience suggests that L-asparaginase-based chemotherapy may improve the prognosis of T-cell PTLD.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume48
Issue number4
Publication statusPublished - 2007 Apr

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Asparaginase
Lymphoproliferative Disorders
Combination Drug Therapy
T-Lymphocytes
Transplants
Palatine Tonsil
Vincristine
Immunosuppressive Agents
Drug Therapy
Dexamethasone
Therapeutics
Biopsy
Deglutition
T-Cell Antigen Receptor
Kidney Transplantation
B-Lymphocytes
Lymph Nodes
Lymphocytes
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Successful treatment with L-asparaginase-based combination chemotherapy for refractory T-cell post-transplant lymphoproliferative disorder. / Mihara, A.; Chen, Chien Kang; Yokoyama, Kenji; Ueda, Tomoki; Tsukada, Yuiko; Awaya, Norihiro; Mori, Takehiko; Ikeda, Yasuo; Okamoto, Shinichiro.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 48, No. 4, 04.2007, p. 305-309.

Research output: Contribution to journalArticle

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