Sudden death of a patient with pandemic influenza (A/H1N1pdm) virus infection by acute respiratory distress syndrome

Akihiro Takiyama, Lei Wang, Mishie Tanino, Taichi Kimura, Naoki Kawagishi, Yasuyuki Kunieda, Harutaka Katano, Noriko Nakajima, Hideki Hasegawa, Tomoyuki Takagi, Hiroshi Nishihara, Tetsutaro Sata, Shinya Tanaka

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We describe an autopsy case of a patient with pandemic influenza (A/H1N1pdm) virus infection in Japan, who developed rapidly progressive viral pneumonia exhibiting diffuse alveolar damage. A 41-year-old female visited our hospital with a fever of 38.7°C. She was a public health nurse with no underlying disease and had had contact with a group of elementary school students who had been infected with the influenza (A/H1N1pdm) virus 1 week earlier. She was prescribed oseltamivir and returned to the hotel where she was staying alone. The next day, she was found dead in her hotel room. At autopsy, both lungs were voluminous and microscopic examination revealed acute-stage, severe diffuse alveolar damage with remarkable mononuclear cell infiltration and hyaline membrane formation in the lungs. CD8-positive T lymphocytes were dominantly observed. Immunohistochemically, influenza A viral protein was confirmed in the damaged type II pneumocytes and also in the infiltrated macrophages. Real-time RT-PCR analysis of both pre- and post-mortem pharyngeal swabs confirmed a novel influenza (A/H1N1pdm) virus infection. This is the second autopsy case of influenza (A/H1N1pdm) virus infection in Japan, and the findings indicated that the patient died due to an exceptionally rapid progression of viral pneumonia. This case indicates that patients with influenza (A/H1N1pdm) virus infection should be carefully monitor for acute respiratory distress syndrome.

Original languageEnglish
Pages (from-to)72-74
Number of pages3
JournalJapanese Journal of Infectious Diseases
Volume63
Issue number1
Publication statusPublished - 2010 Feb 19
Externally publishedYes

Fingerprint

Influenza A virus
Adult Respiratory Distress Syndrome
Pandemics
Virus Diseases
Sudden Death
Viral Pneumonia
Autopsy
Japan
CD8-Positive T-Lymphocytes
Oseltamivir
Public Health Nurses
Alveolar Epithelial Cells
Lung
Hyalin
Viral Proteins
Human Influenza
Real-Time Polymerase Chain Reaction
Fever
Macrophages
Students

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Takiyama, A., Wang, L., Tanino, M., Kimura, T., Kawagishi, N., Kunieda, Y., ... Tanaka, S. (2010). Sudden death of a patient with pandemic influenza (A/H1N1pdm) virus infection by acute respiratory distress syndrome. Japanese Journal of Infectious Diseases, 63(1), 72-74.

Sudden death of a patient with pandemic influenza (A/H1N1pdm) virus infection by acute respiratory distress syndrome. / Takiyama, Akihiro; Wang, Lei; Tanino, Mishie; Kimura, Taichi; Kawagishi, Naoki; Kunieda, Yasuyuki; Katano, Harutaka; Nakajima, Noriko; Hasegawa, Hideki; Takagi, Tomoyuki; Nishihara, Hiroshi; Sata, Tetsutaro; Tanaka, Shinya.

In: Japanese Journal of Infectious Diseases, Vol. 63, No. 1, 19.02.2010, p. 72-74.

Research output: Contribution to journalArticle

Takiyama, A, Wang, L, Tanino, M, Kimura, T, Kawagishi, N, Kunieda, Y, Katano, H, Nakajima, N, Hasegawa, H, Takagi, T, Nishihara, H, Sata, T & Tanaka, S 2010, 'Sudden death of a patient with pandemic influenza (A/H1N1pdm) virus infection by acute respiratory distress syndrome', Japanese Journal of Infectious Diseases, vol. 63, no. 1, pp. 72-74.
Takiyama, Akihiro ; Wang, Lei ; Tanino, Mishie ; Kimura, Taichi ; Kawagishi, Naoki ; Kunieda, Yasuyuki ; Katano, Harutaka ; Nakajima, Noriko ; Hasegawa, Hideki ; Takagi, Tomoyuki ; Nishihara, Hiroshi ; Sata, Tetsutaro ; Tanaka, Shinya. / Sudden death of a patient with pandemic influenza (A/H1N1pdm) virus infection by acute respiratory distress syndrome. In: Japanese Journal of Infectious Diseases. 2010 ; Vol. 63, No. 1. pp. 72-74.
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