Sulfated zirconia (SO4/ZrO2) as a reusable solid acid catalyst for the Mannich-type reaction between ketene silyl acetals and aldimines

Sainan Wang, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Sulfated zirconia (SO4/ZrO2) catalyzed Mannich-type reactions of ketene silyl acetals and aldimines proceeded smoothly at room temperature to afford β-amino esters in good to high yields. In addition, the heterogeneous solid acid catalyst SO4/ZrO2 was easily recovered from the reaction mixture and then reused without significant loss of effectiveness.

Original languageEnglish
Pages (from-to)6449-6452
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number37
DOIs
Publication statusPublished - 2007 Sep 10

Keywords

  • Aldimine
  • Ketene silyl acetal
  • Mannich-type reaction
  • Solid acid
  • Sulfated zirconia

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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