Sulfoconjugation of bisphenol A in a human neuroblastoma cell line, NB-1

Yoshio Ishii, Hiro Omi Tamura

Research output: Contribution to journalArticle

Abstract

Bisphenol A (BPA) is a common environmental endocrine disruptor and BPA sulfate has been demonstrated as one of metabolites of BPA. Since it has been observed to have effects on the central nervous system (CNS), we examined the effects of sulfoconjugation on the toxicity of BPA in a human neuroblastoma cell line, NB-1. NB-1 cells showed limited but significant sulfotransferase activity toward BPA in vitro (Km = 74 μM, Vmax = 7.8 pmol/min/mg). Accumulation of BPA sulfate was observed for 12 hr to 4 days after 10 μM BPA was added to a culture of NB-1 cells. These results suggest that BPA is partly detoxified by the sulfoconjugation reaction in human neuronal cells.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalJournal of Health Science
Volume49
Issue number4
DOIs
Publication statusPublished - 2003 Aug

Keywords

  • Bisphenol A
  • Brain
  • NB-1
  • Neuron
  • Sulfotransferase

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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