Sunitinib-induced severe toxicities in a japanese patient with the ABCG2 421 AA genotype

Medicine & Life Sciences

• Sunitinib 100%
• Genotype 55%
• SU 12662 36%
• Hand-Foot Syndrome 8%
• Vascular Endothelial Growth Factor Receptor 7%
• Platelet-Derived Growth Factor 6%
• Pharmacogenetics 6%
• Pulmonary Edema 6%
• Receptor Protein-Tyrosine Kinases 6%
• Pleural Effusion 6%
• Transaminases 6%
• Gene Frequency 5%
• Renal Cell Carcinoma 5%
• Thrombocytopenia 5%
• Drug-Related Side Effects and Adverse Reactions 5%
• Vomiting 5%
• Single Nucleotide Polymorphism 5%
• Diarrhea 4%
• Hypoxia 4%
• Adenosine Triphosphate 4%
• Pharmacokinetics 4%
• Fever 4%
• Alleles 4%
• Therapeutics 3%
• Hypertension 3%
• Neoplasms 1%