[13C] breath test of medium-chain triglycerides and oligosaccharides in neonates

J. Hoshi, H. Nishida, Masato Yasui, M. Ohishi, M. Takahashi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

It is suitable to examine the utilization of carbohydrates and fats using stable isotope-labelled substrates in neonates because of their non-radioactivity. Administering medium chain triglycerides (MCT) and oligosaccharides is of use in enteral nutrition for a patient with a limited water intake such as a neonate. In this study, the oxidation of MCT and maltose administered orally as an energy supplement in neonates has been examined using a stable isotope-labelled breath test. Five normal term neonates and five growing preterm infants were given [13C]-trioctanoin orally and three growing preterm infants were given [13C]-glucose and [13C]-maltose orally. The [13C] enrichment in carbon dioxide was analyzed by isotope ratio mass spectrometry, and oxidation rates over 6 hr and 12 hr respectively, were calculated. The oxidation rates for [13C]-octanoin after 6 hr were 46.2 ± 3.6% in preterm infants and 53.5 ± 13.8% in normal neonates, respectively (no significant difference), and 58.4 ± 9.4% and 52.8 ± 6.0% for [13C]-glucose and [13C]-maltose, respectively (not significant). The results demonstrate that orally administered MCT and maltose are oxidized sufficiently in preterm infants.

Original languageEnglish
Pages (from-to)674-677
Number of pages4
JournalActa Paediatrica Japonica (Overseas Edition)
Volume34
Issue number6
Publication statusPublished - 1992
Externally publishedYes

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Breath Tests
Oligosaccharides
Maltose
Triglycerides
Premature Infants
Newborn Infant
Isotopes
Glucose
Enteral Nutrition
Carbon Dioxide
Drinking
Mass Spectrometry
Fats
Carbohydrates

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

[13C] breath test of medium-chain triglycerides and oligosaccharides in neonates. / Hoshi, J.; Nishida, H.; Yasui, Masato; Ohishi, M.; Takahashi, M.

In: Acta Paediatrica Japonica (Overseas Edition), Vol. 34, No. 6, 1992, p. 674-677.

Research output: Contribution to journalArticle

Hoshi, J. ; Nishida, H. ; Yasui, Masato ; Ohishi, M. ; Takahashi, M. / [13C] breath test of medium-chain triglycerides and oligosaccharides in neonates. In: Acta Paediatrica Japonica (Overseas Edition). 1992 ; Vol. 34, No. 6. pp. 674-677.
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