Superior hepatic mitochondrial oxidation-reduction state in normothermic cardiopulmonary bypass

Kazuhiro Hashimoto, Tatsuumi Sasaki, Takashi Hachiya, Katsuhisa Onoguchi, Hiromitsu Takakura, Motohiro Oshiumi, Shigeyuki Takeuchi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: This study is the first comparative investigation of hepatic blood flow and oxygen metabolism during normothermic and hypothermic cardiopulmonary bypass. Methods: Twenty-four patients undergoing coronary bypass operations were randomly divided into 2 groups according to their perfusion temperatures, either normothermia (36°C) or hypothermia (30°C). The clearance of indocyanine green was measured at 3 points. Arterial and hepatic venous ketone body ratios (an index of mitochondrial redox potential) and hepatic venous saturation were measured. Results: Hepatic blood flow in both groups was identical before, during, and after cardiopulmonary bypass (normothermia, 499 ± 111, 479 ± 139, and 563 ± 182 mL/min, respectively; hypothermia, 476 ± 156, 491 ± 147, and 560 ± 202 mL/min, respectively). The hepatic venous saturation levels were significantly lower during cardiopulmonary bypass in the normothermic group (normothermia, 41% ± 13%; hypothermia, 61% ± 18%; P <.01), indicating a higher level of oxygen extraction use. The arterial ketone body ratio in the hypothermic group decreased severely after the onset of cardiopulmonary bypass (P <.01) and did not return to its subnormal value (>0.7) until the second postoperative day. However, the reduction in arterial ketone body ratio was less severe in the normothermic group. The difference in hepatic venous ketone body ratios was more obvious, and the hepatic venous ketone body ratios in the normothermic group were statistically superior to those of the hypothermic group throughout the course (P < .05-.01). Conclusions: Normothermic cardiopulmonary bypass provides adequate liver perfusion and results in a better hepatic mitochondrial redox potential than hypothermic cardiopulmonary bypass. Because arterial ketone body ratios reflect hepatic energy potential, normothermia was considered to be physiologically more advantageous for hepatic function.

Original languageEnglish
Pages (from-to)1179-1186
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume121
Issue number6
DOIs
Publication statusPublished - 2001 Jun 1

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Cardiopulmonary Bypass
Oxidation-Reduction
Ketone Bodies
Liver
Hypothermia
Perfusion
Indocyanine Green
Oxygen
Temperature

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Hashimoto, K., Sasaki, T., Hachiya, T., Onoguchi, K., Takakura, H., Oshiumi, M., & Takeuchi, S. (2001). Superior hepatic mitochondrial oxidation-reduction state in normothermic cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery, 121(6), 1179-1186. https://doi.org/10.1067/mtc.2001.113599

Superior hepatic mitochondrial oxidation-reduction state in normothermic cardiopulmonary bypass. / Hashimoto, Kazuhiro; Sasaki, Tatsuumi; Hachiya, Takashi; Onoguchi, Katsuhisa; Takakura, Hiromitsu; Oshiumi, Motohiro; Takeuchi, Shigeyuki.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 121, No. 6, 01.06.2001, p. 1179-1186.

Research output: Contribution to journalArticle

Hashimoto, K, Sasaki, T, Hachiya, T, Onoguchi, K, Takakura, H, Oshiumi, M & Takeuchi, S 2001, 'Superior hepatic mitochondrial oxidation-reduction state in normothermic cardiopulmonary bypass', Journal of Thoracic and Cardiovascular Surgery, vol. 121, no. 6, pp. 1179-1186. https://doi.org/10.1067/mtc.2001.113599
Hashimoto, Kazuhiro ; Sasaki, Tatsuumi ; Hachiya, Takashi ; Onoguchi, Katsuhisa ; Takakura, Hiromitsu ; Oshiumi, Motohiro ; Takeuchi, Shigeyuki. / Superior hepatic mitochondrial oxidation-reduction state in normothermic cardiopulmonary bypass. In: Journal of Thoracic and Cardiovascular Surgery. 2001 ; Vol. 121, No. 6. pp. 1179-1186.
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