Superiority of radioisotope over blue dye for sentinel lymph node detection in breast cancer

Tetsu Hayashida, H. Jinno, M. Sakata, Maiko Takahashi, T. Onishi, H. Seki, T. Sato, Tadaki Nakahara, Naoyuki Shigematsu, M. Mukai, T. Hibi, M. Kitajima, Yuukou Kitagawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Sentinel lymph node biopsy (SLNB) is commonly performed using radioisotopes and/or blue dye. However, it is still undefined which reagent is more suitable for identifying sentinel lymph nodes (SLN). Patients and Methods: A consecutive series of 640 breast cancer patients who had undergone SLNB at the Keio University Hospital from 2001 to 2006 was analyzed. The SLN was identified by a combination of technetium-99m tin colloid and isosulfan blue dye. The correlation between clinicopathological factors and the distribution of radioisotopes and blue dye was analyzed. The single metastatic lymph node revealed by axillary lymph node dissection (ALND) is the 'true SLN', and the distribution of radioisotopes and blue dye to the 'true SLN' was also analyzed. Results: Blue-dye- and radioisotope-positive SLN were identified in 79.6 and 94.7% of the patients, respectively. Taken together, SLN were identified in 625 patients (97.7%) by radioisotope and/or blue dye. No significant correlation was observed between clinicopathological features and the distribution of the reagents. ALND found 73 patients with single lymph node metastasis, and 73 'true SLN' were identified by blue dye in 65.7% (48/73), and by radioisotope in 95.9% (70/73) of the cases. Conclusion: These data suggest that radioisotopes are superior to blue dye in detecting SLN in breast cancer.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalEuropean Surgical Research
Volume44
Issue number2
DOIs
Publication statusPublished - 2010 Feb

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Radioisotopes
Coloring Agents
Breast Neoplasms
Sentinel Lymph Node Biopsy
Lymph Node Excision
Lymph Nodes
Sentinel Lymph Node
Technetium
Neoplasm Metastasis

Keywords

  • Breast cancer
  • Isosulfan blue dye
  • Radioisotope
  • Sentinel lymph node

ASJC Scopus subject areas

  • Surgery

Cite this

Superiority of radioisotope over blue dye for sentinel lymph node detection in breast cancer. / Hayashida, Tetsu; Jinno, H.; Sakata, M.; Takahashi, Maiko; Onishi, T.; Seki, H.; Sato, T.; Nakahara, Tadaki; Shigematsu, Naoyuki; Mukai, M.; Hibi, T.; Kitajima, M.; Kitagawa, Yuukou.

In: European Surgical Research, Vol. 44, No. 2, 02.2010, p. 111-116.

Research output: Contribution to journalArticle

Hayashida, Tetsu ; Jinno, H. ; Sakata, M. ; Takahashi, Maiko ; Onishi, T. ; Seki, H. ; Sato, T. ; Nakahara, Tadaki ; Shigematsu, Naoyuki ; Mukai, M. ; Hibi, T. ; Kitajima, M. ; Kitagawa, Yuukou. / Superiority of radioisotope over blue dye for sentinel lymph node detection in breast cancer. In: European Surgical Research. 2010 ; Vol. 44, No. 2. pp. 111-116.
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abstract = "Background: Sentinel lymph node biopsy (SLNB) is commonly performed using radioisotopes and/or blue dye. However, it is still undefined which reagent is more suitable for identifying sentinel lymph nodes (SLN). Patients and Methods: A consecutive series of 640 breast cancer patients who had undergone SLNB at the Keio University Hospital from 2001 to 2006 was analyzed. The SLN was identified by a combination of technetium-99m tin colloid and isosulfan blue dye. The correlation between clinicopathological factors and the distribution of radioisotopes and blue dye was analyzed. The single metastatic lymph node revealed by axillary lymph node dissection (ALND) is the 'true SLN', and the distribution of radioisotopes and blue dye to the 'true SLN' was also analyzed. Results: Blue-dye- and radioisotope-positive SLN were identified in 79.6 and 94.7{\%} of the patients, respectively. Taken together, SLN were identified in 625 patients (97.7{\%}) by radioisotope and/or blue dye. No significant correlation was observed between clinicopathological features and the distribution of the reagents. ALND found 73 patients with single lymph node metastasis, and 73 'true SLN' were identified by blue dye in 65.7{\%} (48/73), and by radioisotope in 95.9{\%} (70/73) of the cases. Conclusion: These data suggest that radioisotopes are superior to blue dye in detecting SLN in breast cancer.",
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AU - Onishi, T.

AU - Seki, H.

AU - Sato, T.

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