Abstract
The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.
| Original language | English |
|---|---|
| Pages (from-to) | 547-551 |
| Number of pages | 5 |
| Journal | Archives of Biochemistry and Biophysics |
| Volume | 254 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1987 May 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Superoxide radical initiates the autoxidation of dihydroxyacetone. / Mashino, Tadahiko; Fridovich, Irwin.
In: Archives of Biochemistry and Biophysics, Vol. 254, No. 2, 01.05.1987, p. 547-551.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Superoxide radical initiates the autoxidation of dihydroxyacetone
AU - Mashino, Tadahiko
AU - Fridovich, Irwin
PY - 1987/5/1
Y1 - 1987/5/1
N2 - The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.
AB - The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.
UR - http://www.scopus.com/inward/record.url?scp=0023333090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023333090&partnerID=8YFLogxK
U2 - 10.1016/0003-9861(87)90136-6
DO - 10.1016/0003-9861(87)90136-6
M3 - Article
C2 - 3034165
AN - SCOPUS:0023333090
VL - 254
SP - 547
EP - 551
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
SN - 0003-9861
IS - 2
ER -