Superoxide radical initiates the autoxidation of dihydroxyacetone

Tadahiko Mashino, Irwin Fridovich

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.

Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalArchives of Biochemistry and Biophysics
Volume254
Issue number2
DOIs
Publication statusPublished - 1987 May 1
Externally publishedYes

Fingerprint

Dihydroxyacetone
Iron Chelating Agents
Xanthine Oxidase
Sugars
Superoxides
Catalase
Superoxide Dismutase
Free Radicals
Chelating Agents
Iron
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Superoxide radical initiates the autoxidation of dihydroxyacetone. / Mashino, Tadahiko; Fridovich, Irwin.

In: Archives of Biochemistry and Biophysics, Vol. 254, No. 2, 01.05.1987, p. 547-551.

Research output: Contribution to journalArticle

@article{51fa2332094e47eca1e2a2d7169853da,
title = "Superoxide radical initiates the autoxidation of dihydroxyacetone",
abstract = "The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.",
author = "Tadahiko Mashino and Irwin Fridovich",
year = "1987",
month = "5",
day = "1",
doi = "10.1016/0003-9861(87)90136-6",
language = "English",
volume = "254",
pages = "547--551",
journal = "Archives of Biochemistry and Biophysics",
issn = "0003-9861",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Superoxide radical initiates the autoxidation of dihydroxyacetone

AU - Mashino, Tadahiko

AU - Fridovich, Irwin

PY - 1987/5/1

Y1 - 1987/5/1

N2 - The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.

AB - The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.

UR - http://www.scopus.com/inward/record.url?scp=0023333090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023333090&partnerID=8YFLogxK

U2 - 10.1016/0003-9861(87)90136-6

DO - 10.1016/0003-9861(87)90136-6

M3 - Article

VL - 254

SP - 547

EP - 551

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

SN - 0003-9861

IS - 2

ER -