Abstract
The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.
Original language | English |
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Pages (from-to) | 547-551 |
Number of pages | 5 |
Journal | Archives of Biochemistry and Biophysics |
Volume | 254 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1987 May 1 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology