Superoxide radical initiates the autoxidation of dihydroxyacetone

Tadahiko Mashino; Irwin Fridovich

doi:10.1016/0003-9861(87)90136-6

Superoxide radical initiates the autoxidation of dihydroxyacetone

Tadahiko Mashino, Irwin Fridovich

Research output: Contribution to journal › Article

39 Citations (Scopus)

Abstract

The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O₂^- introduced. A free radical chain mechanism, in which O₂^- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O₂^-.

Original language	English
Pages (from-to)	547-551
Number of pages	5
Journal	Archives of Biochemistry and Biophysics
Volume	254
Issue number	2
DOIs	https://doi.org/10.1016/0003-9861(87)90136-6
Publication status	Published - 1987 May 1
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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Mashino, T., & Fridovich, I. (1987). Superoxide radical initiates the autoxidation of dihydroxyacetone. Archives of Biochemistry and Biophysics, 254(2), 547-551. https://doi.org/10.1016/0003-9861(87)90136-6

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