Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells

Tamami Yasukagawa, Yuki Niwa, Siro Simizu, Kazuo Umezawa

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

It has been demonstrated that potassium channels (K + channels) play significant roles in some malignant phenotypes. Here, we provide the first evidence that treatment with glybenclamide, an ATP-sensitive K + channel blocker, inhibited cell migration in an ovarian clear cell carcinoma cell line, ES-2. Treatment with glybenclamide or knockdown by siRNA targeted against K + channel subunits demonstrated the suppression of ovarian cancer cell invasion, which occurred via inhibition of PDGF-AA secretion. Therefore, our findings suggest that K + channel blockers may be useful chemotherapeutic drugs for blocking the invasiveness of ovarian cancers.

Original languageEnglish
Pages (from-to)1504-1509
Number of pages6
JournalFEBS Letters
Volume586
Issue number10
DOIs
Publication statusPublished - 2012 May 21

Keywords

  • Glybenclamide
  • Ovarian cancer
  • Platelet-derived growth factor
  • Potassium channel
  • Trafficking
  • Tumor invasion

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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