Suppression of in vitro granulocyte-macrophage colony formation by the peripheral mononuclear phagocytic cells of patients with idiopathic aplastic anaemia

T. Suda, H. Mizoguchi, Y. Miura, K. Kubota, F. Takaku

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12 Citations (Scopus)

Abstract

To investigate whether phagocytic cells play a role in the pathogenesis of aplastic anaemia, the authors studied the effect of the mononuclear phagocytic cells in the peripheral blood from patients with idiopathic aplastic anaemia on granulocyte-macrophage colony (GM-colony) formation. There was no apparent infection in the studied patients. In 9 out of 20 cases the mononuclear cells suppressed the formation of GM-colonies by normal bone marrow. Removal of the phagocytic cells by carbonyl iron powder caused a loss of this suppressive effect. These results suggest the requirement for phagocytic cells in this suppressive effect and the possible involvement of phagocyte-mediated immunological mechanism in the pathogenesis of some cases of idiopathic aplastic anaemia.

Original languageEnglish
Pages (from-to)433-442
Number of pages10
JournalBritish Journal of Haematology
Volume47
Issue number3
Publication statusPublished - 1981

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Phagocytes
Granulocytes
Macrophages
Aplastic Anemia
Powders
Iron
Bone Marrow
In Vitro Techniques
Idiopathic Aplastic anemia
Infection

ASJC Scopus subject areas

  • Hematology

Cite this

Suppression of in vitro granulocyte-macrophage colony formation by the peripheral mononuclear phagocytic cells of patients with idiopathic aplastic anaemia. / Suda, T.; Mizoguchi, H.; Miura, Y.; Kubota, K.; Takaku, F.

In: British Journal of Haematology, Vol. 47, No. 3, 1981, p. 433-442.

Research output: Contribution to journalArticle

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