Abstract
Migrastatin (MGS) is a Streptomyces metabolite that inhibits cancer cell migration. In this study, we found that MGS also enhanced the cytotoxicity of vinblastine, vincristine, and taxol in P-glycoprotein-overexpressing VJ-300 cells and P388/VCR cells. Furthermore, MGS increased the intracellular concentration of labeled vinblastine, vincristine, and taxol in both VJ-300 cells and P388/VCR cells. P-glycoprotein was photolabeled with [ 3H]azidopine, but this photolabeling was significantly inhibited in the presence of MGS. These results indicated that MGS directly interacts with and inhibits P-glycoprotein, thereby sensitizing drug-resistant cells to anticancer drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 435-438 |
| Number of pages | 4 |
| Journal | Journal of Antibiotics |
| Volume | 59 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2006 Jul |
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Keywords
- Anticancer drugs
- Migrastatin
- Multi drug resistance
- P-glycoprotein
ASJC Scopus subject areas
- Pharmacology
- Molecular Medicine
Cite this
Suppression of multidrug resistance by migrastatin. / Takemoto, Yasushi; Tashiro, Etsu; Imoto, Masaya.
In: Journal of Antibiotics, Vol. 59, No. 7, 07.2006, p. 435-438.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of multidrug resistance by migrastatin
AU - Takemoto, Yasushi
AU - Tashiro, Etsu
AU - Imoto, Masaya
PY - 2006/7
Y1 - 2006/7
N2 - Migrastatin (MGS) is a Streptomyces metabolite that inhibits cancer cell migration. In this study, we found that MGS also enhanced the cytotoxicity of vinblastine, vincristine, and taxol in P-glycoprotein-overexpressing VJ-300 cells and P388/VCR cells. Furthermore, MGS increased the intracellular concentration of labeled vinblastine, vincristine, and taxol in both VJ-300 cells and P388/VCR cells. P-glycoprotein was photolabeled with [ 3H]azidopine, but this photolabeling was significantly inhibited in the presence of MGS. These results indicated that MGS directly interacts with and inhibits P-glycoprotein, thereby sensitizing drug-resistant cells to anticancer drugs.
AB - Migrastatin (MGS) is a Streptomyces metabolite that inhibits cancer cell migration. In this study, we found that MGS also enhanced the cytotoxicity of vinblastine, vincristine, and taxol in P-glycoprotein-overexpressing VJ-300 cells and P388/VCR cells. Furthermore, MGS increased the intracellular concentration of labeled vinblastine, vincristine, and taxol in both VJ-300 cells and P388/VCR cells. P-glycoprotein was photolabeled with [ 3H]azidopine, but this photolabeling was significantly inhibited in the presence of MGS. These results indicated that MGS directly interacts with and inhibits P-glycoprotein, thereby sensitizing drug-resistant cells to anticancer drugs.
KW - Anticancer drugs
KW - Migrastatin
KW - Multi drug resistance
KW - P-glycoprotein
UR - http://www.scopus.com/inward/record.url?scp=33748933205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748933205&partnerID=8YFLogxK
U2 - 10.1038/ja.2006.62
DO - 10.1038/ja.2006.62
M3 - Article
C2 - 17025021
AN - SCOPUS:33748933205
VL - 59
SP - 435
EP - 438
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 7
ER -