Abstract
Migrastatin (MGS) is a Streptomyces metabolite that inhibits cancer cell migration. In this study, we found that MGS also enhanced the cytotoxicity of vinblastine, vincristine, and taxol in P-glycoprotein-overexpressing VJ-300 cells and P388/VCR cells. Furthermore, MGS increased the intracellular concentration of labeled vinblastine, vincristine, and taxol in both VJ-300 cells and P388/VCR cells. P-glycoprotein was photolabeled with [ 3H]azidopine, but this photolabeling was significantly inhibited in the presence of MGS. These results indicated that MGS directly interacts with and inhibits P-glycoprotein, thereby sensitizing drug-resistant cells to anticancer drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 435-438 |
| Number of pages | 4 |
| Journal | Journal of Antibiotics |
| Volume | 59 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2006 Jul 1 |
Keywords
- Anticancer drugs
- Migrastatin
- Multi drug resistance
- P-glycoprotein
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
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Cite this
Takemoto, Y., Tashiro, E., & Imoto, M. (2006). Suppression of multidrug resistance by migrastatin. Journal of Antibiotics, 59(7), 435-438. https://doi.org/10.1038/ja.2006.62