Abstract
Migrastatin (MGS) is a Streptomyces metabolite that inhibits cancer cell migration. In this study, we found that MGS also enhanced the cytotoxicity of vinblastine, vincristine, and taxol in P-glycoprotein-overexpressing VJ-300 cells and P388/VCR cells. Furthermore, MGS increased the intracellular concentration of labeled vinblastine, vincristine, and taxol in both VJ-300 cells and P388/VCR cells. P-glycoprotein was photolabeled with [ 3H]azidopine, but this photolabeling was significantly inhibited in the presence of MGS. These results indicated that MGS directly interacts with and inhibits P-glycoprotein, thereby sensitizing drug-resistant cells to anticancer drugs.
Original language | English |
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Pages (from-to) | 435-438 |
Number of pages | 4 |
Journal | Journal of Antibiotics |
Volume | 59 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2006 Jul |
Keywords
- Anticancer drugs
- Migrastatin
- Multi drug resistance
- P-glycoprotein
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery