Suppressor T cell function in patients with rheumatoid arthritis complicated by vasculitis

T. Abe, Tsutomu Takeuchi, J. Koide, O. Hosono, M. Homma, C. Morimoto, R. Yokohari

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Concanavalin A (Con A)-induced suppressor T cell activity was determined in 10 rheumatoid arthritis (RA) patients with vasculitis, 34 RA patients without vasculitis, and 10 healthy individuals. The percent Con A-induced suppression in RA patients with vasculitis was 24.6. In contrast, it was 68.4% in those RA patients without vascular lesions. Further, the proportion of T cells reactive with OKT8 monoclonal antibody was also decreased in RA patients with vasculitis. Accordingly, the reduced Con A-induced suppressor T cell activity in these RA patients resulted, in part, from the reduction in the number of cells of the suppressor T cell subset. Those patients with vascular lesions also had a higher percentage of positive antilymphocytotoxic antibodies than RA patients without vasculitis. Since the differences in Con A-induced suppressor T cell activity and frequency of positive antilymphocytotoxic antibodies were so great, we believe RA patients with vasculitis could be recognized as a disease group distinct from RA patients without vasculitis.

Original languageEnglish
Pages (from-to)752-759
Number of pages8
JournalArthritis and Rheumatism
Volume27
Issue number7
Publication statusPublished - 1984

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Vasculitis
Rheumatoid Arthritis
T-Lymphocytes
Concanavalin A
Blood Vessels
Antibodies
T-Lymphocyte Subsets
Cell Count
Monoclonal Antibodies

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Abe, T., Takeuchi, T., Koide, J., Hosono, O., Homma, M., Morimoto, C., & Yokohari, R. (1984). Suppressor T cell function in patients with rheumatoid arthritis complicated by vasculitis. Arthritis and Rheumatism, 27(7), 752-759.

Suppressor T cell function in patients with rheumatoid arthritis complicated by vasculitis. / Abe, T.; Takeuchi, Tsutomu; Koide, J.; Hosono, O.; Homma, M.; Morimoto, C.; Yokohari, R.

In: Arthritis and Rheumatism, Vol. 27, No. 7, 1984, p. 752-759.

Research output: Contribution to journalArticle

Abe, T, Takeuchi, T, Koide, J, Hosono, O, Homma, M, Morimoto, C & Yokohari, R 1984, 'Suppressor T cell function in patients with rheumatoid arthritis complicated by vasculitis', Arthritis and Rheumatism, vol. 27, no. 7, pp. 752-759.
Abe, T. ; Takeuchi, Tsutomu ; Koide, J. ; Hosono, O. ; Homma, M. ; Morimoto, C. ; Yokohari, R. / Suppressor T cell function in patients with rheumatoid arthritis complicated by vasculitis. In: Arthritis and Rheumatism. 1984 ; Vol. 27, No. 7. pp. 752-759.
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