Suppressors of cytokine signaling and immunity

Masato Kubo, Toshikatu Hanada, Akihiko Yoshimura

Research output: Contribution to journalReview articlepeer-review

544 Citations (Scopus)


The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.

Original languageEnglish
Pages (from-to)1169-1176
Number of pages8
JournalNature Immunology
Issue number12
Publication statusPublished - 2003 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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