Suppressors of cytokine signaling and immunity

Masato Kubo, Toshikatu Hanada, Akihiko Yoshimura

Research output: Contribution to journalArticle

483 Citations (Scopus)

Abstract

The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.

Original languageEnglish
Pages (from-to)1169-1176
Number of pages8
JournalNature Immunology
Volume4
Issue number12
DOIs
Publication statusPublished - 2003 Dec
Externally publishedYes

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Immunity
Cytokines
Viral Tumor Antigens
Adaptive Immunity
Antigen-Presenting Cells
Innate Immunity
Dendritic Cells
Immune System
Macrophages
T-Lymphocytes
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Suppressors of cytokine signaling and immunity. / Kubo, Masato; Hanada, Toshikatu; Yoshimura, Akihiko.

In: Nature Immunology, Vol. 4, No. 12, 12.2003, p. 1169-1176.

Research output: Contribution to journalArticle

Kubo, Masato ; Hanada, Toshikatu ; Yoshimura, Akihiko. / Suppressors of cytokine signaling and immunity. In: Nature Immunology. 2003 ; Vol. 4, No. 12. pp. 1169-1176.
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