Suppressors of cytokine signaling and immunity

Masato Kubo; Toshikatu Hanada; Akihiko Yoshimura

doi:10.1038/ni1012

Suppressors of cytokine signaling and immunity

Masato Kubo, Toshikatu Hanada, Akihiko Yoshimura

Research output: Contribution to journal › Review article › peer-review

544 Citations (Scopus)

Abstract

The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.

Original language	English
Pages (from-to)	1169-1176
Number of pages	8
Journal	Nature Immunology
Volume	4
Issue number	12
DOIs	https://doi.org/10.1038/ni1012
Publication status	Published - 2003 Dec
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/ni1012

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abstract = "The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.",

author = "Masato Kubo and Toshikatu Hanada and Akihiko Yoshimura",

year = "2003",

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AB - The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.

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Suppressors of cytokine signaling and immunity

Abstract

ASJC Scopus subject areas

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